Inhibition of ferroptosis attenuates tissue damage and improves long‐term outcomes after traumatic brain injury in mice

BS Xie, YQ Wang, Y Lin, Q Mao, JF Feng… - CNS neuroscience & …, 2019 - Wiley Online Library
Aims Ferroptosis, a new form of iron‐dependent programmed cell death, has been shown to
be involved in a range of diseases. However, the role of ferroptosis in traumatic brain injury …

Crocetin promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway

A Wani, SB Al Rihani, A Sharma, B Weadick… - Autophagy, 2021 - Taylor & Francis
Alzheimer disease (AD) is usually accompanied by two prominent pathological features,
cerebral accumulation of amyloid-β (Aβ) plaques and presence of MAPT/tau neurofibrillary …

[HTML][HTML] Increased level of exosomal miR-20b-5p derived from hypothermia-treated microglia promotes neurite outgrowth and synapse recovery after traumatic brain …

C Wang, Y Ji, H Zhang, Y Ye, G Zhang, S Zhang… - Neurobiology of …, 2023 - Elsevier
Mild hypothermia has been proven to inhibit microglia activation after TBI. Exosomal
microRNA derived from microglia played a critical role in promoting neurite outgrowth and …

Ursolic acid ameliorates traumatic brain injury in mice by regulating microRNA-141-mediated PDCD4/PI3K/AKT signaling pathway

H Zhang, Z Xing, J Zheng, J Shi, C Cui - International …, 2023 - Elsevier
Background Neuronal apoptosis and inflammation are the key pathogenic features of
secondary brain injury, which results in the neurological impairment that traumatic brain …

Oleocanthal-rich extra-virgin olive oil restores the blood–brain barrier function through NLRP3 inflammasome inhibition simultaneously with autophagy induction in …

SB Al Rihani, LI Darakjian… - ACS chemical …, 2019 - ACS Publications
Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by
multiple hallmarks including extracellular amyloid (Aβ) plaques, neurofibrillary tangles …

[HTML][HTML] Deferoxamine reduces endothelial ferroptosis and protects cerebrovascular function after experimental traumatic brain injury

Y Liang, Y Wang, C Sun, Y Xiang, Y Deng - Brain Research Bulletin, 2024 - Elsevier
Cerebrovascular dysfunction resulting from traumatic brain injury (TBI) significantly
contributes to poor patient outcomes. Recent studies revealed the involvement of iron …

[HTML][HTML] Is temperature an important variable in recovery after mild traumatic brain injury?

CM Atkins, HM Bramlett, WD Dietrich - F1000Research, 2017 - ncbi.nlm.nih.gov
With nearly 42 million mild traumatic brain injuries (mTBIs) occurring worldwide every year,
understanding the factors that may adversely influence recovery after mTBI is important for …

The influence of body temperature on tissue stiffness, blood perfusion, and water diffusion in the mouse brain

G Bertalan, P Boehm-Sturm, S Schreyer, AS Morr… - Acta Biomaterialia, 2019 - Elsevier
While hypothermia of the brain is used to reduce neuronal damage in patients with
conditions such as traumatic brain injury or stroke, little is known about how temperature …

[HTML][HTML] Bumetanide prevents brain trauma-induced depressive-like behavior

E Goubert, M Altvater, MN Rovira, I Khalilov… - Frontiers in molecular …, 2019 - frontiersin.org
Brain trauma triggers a cascade of deleterious events leading to enhanced incidence of
drug resistant epilepsies, depression, and cognitive dysfunctions. The underlying …

The overexpression of RBM3 alleviates TBI‐induced behaviour impairment and AD‐like tauopathy in mice

B Liu, Y Cao, F Shi, L Wang, N Li… - Journal of Cellular …, 2020 - Wiley Online Library
The therapeutic hypothermia is an effective tool for TBI‐associated brain impairment, but its
side effects limit in clinical routine use. Hypothermia up‐regulates RNA‐binding motif protein …