[HTML][HTML] hERG K+ channels: structure, function, and clinical significance
The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …
Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia
About 10 distinct potassium channels in the heart are involved in shaping the action
potential. Some of the K+ channels are primarily responsible for early repolarization …
potential. Some of the K+ channels are primarily responsible for early repolarization …
Arrhythmia in heart and brain: KCNQ1 mutations link epilepsy and sudden unexplained death
AM Goldman, E Glasscock, J Yoo, TT Chen… - Science translational …, 2009 - science.org
Sudden unexplained death is a catastrophic complication of human idiopathic epilepsy,
causing up to 18% of patient deaths. A molecular mechanism and an identified therapy have …
causing up to 18% of patient deaths. A molecular mechanism and an identified therapy have …
The MinK-related peptides
ZA McCrossan, GW Abbott - Neuropharmacology, 2004 - Elsevier
Voltage-gated potassium (Kv) channels mediate rapid, selective diffusion of K+ ions through
the plasma membrane, controlling cell excitability, secretion and signal transduction. KCNE …
the plasma membrane, controlling cell excitability, secretion and signal transduction. KCNE …
Cardiac IKr channels minimally comprise hERG 1a and 1b subunits
EMC Jones, ECR Roti, J Wang, SA Delfosse… - Journal of Biological …, 2004 - ASBMB
Previous studies suggest native cardiac I Kr channels are composed of alpha subunits
encoded solely by the 1a transcript of the ERG1 gene. Using isoform-specific ERG1 …
encoded solely by the 1a transcript of the ERG1 gene. Using isoform-specific ERG1 …
Differential gene expressions in atrial and ventricular myocytes: insights into the road of applying embryonic stem cell-derived cardiomyocytes for future therapies
SY Ng, CK Wong, SY Tsang - American journal of …, 2010 - journals.physiology.org
Myocardial infarction has been the leading cause of morbidity and mortality in developed
countries over the past few decades. The transplantation of cardiomyocytes offers a potential …
countries over the past few decades. The transplantation of cardiomyocytes offers a potential …
KCNE1 and KCNE3: The yin and yang of voltage-gated K+ channel regulation
GW Abbott - Gene, 2016 - Elsevier
The human KCNE gene family comprises five genes encoding single transmembrane-
spanning ion channel regulatory subunits. The primary function of KCNE subunits appears …
spanning ion channel regulatory subunits. The primary function of KCNE subunits appears …
[HTML][HTML] Structural and electro-anatomical characterization of the equine pulmonary veins: implications for atrial fibrillation
Introduction/objectives Spontaneous pulmonary vein (PV) activity triggers atrial fibrillation
(AF) in humans. Although AF frequently occurs in horses, the origin remains unknown. This …
(AF) in humans. Although AF frequently occurs in horses, the origin remains unknown. This …
MinK-related peptide 2 modulates Kv2. 1 and Kv3. 1 potassium channels in mammalian brain
ZA McCrossan, A Lewis, G Panaghie… - Journal of …, 2003 - Soc Neuroscience
Delayed rectifier potassium current diversity and regulation are essential for signal
processing and integration in neuronal circuits. Here, we investigated a neuronal role for …
processing and integration in neuronal circuits. Here, we investigated a neuronal role for …
Molecular basis of functional myocardial potassium channel diversity
JM Nerbonne - Cardiac electrophysiology clinics, 2016 - cardiacep.theclinics.com
The normal mechanical functioning of the mammalian heart depends on proper electrical
function, evident in the sequential generation of action potentials in cells in the “pacemaker” …
function, evident in the sequential generation of action potentials in cells in the “pacemaker” …