Voltage‐gated sodium channels initiate action potentials in nerve, muscle and other
excitable cells. The sodium current that initiates the nerve action potential was discovered by …

The voltage-gated sodium channel NaV1. 7 is preferentially expressed in peripheral somatic
and visceral sensory neurons, olfactory sensory neurons and sympathetic ganglion neurons …

Voltage-gated sodium channel Nav1. 7 represents a promising target for pain relief. Here we
report the cryo–electron microscopy structures of the human Nav1. 7-β1-β2 complex bound …

2. Background The history behind this change dates back several years with a long, and at
times, heated debate about the inclusion of the term “dysfunction”[5]. Clinicians with …

Voltage-gated sodium (Nav) channels are targets of disease mutations, toxins, and
therapeutic drugs. Despite recent advances, the structural basis of voltage sensing …

Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect
experienced by cancer patients receiving treatment with paclitaxel. The voltage-gated …

Trigeminal neuralgia (TN) is a complex orofacial pain syndrome characterized by the
paroxysmal onset of pain attacks in the trigeminal distribution. The underlying mechanism …

Voltage-gated ion channels generate electrical signals in species from bacteria to man.
Their voltage-sensing modules are responsible for initiation of action potentials and graded …

Nociception is essential for survival whereas pathological pain is maladaptive and often
unresponsive to pharmacotherapy. Voltage-gated sodium channels, Nav1. 1–Nav1. 9, are …

Human monogenic pain syndromes have provided important insights into the molecular
mechanisms that underlie normal and pathological pain states. We describe an autosomal …