Inflammation is an immediate response that plays a critical role in healing after fracture or
injury to bone. However, in certain clinical contexts, such as in inflammatory diseases or in …

These animal data, together with the view of limited scientifically robust clinical evidence in
humans, indicate that physicians consider only short-term administration of COX-2 inhibitors …

The purpose of this study was to review the effects of nonsteroidal anti-inflammatory drugs
on osseointegration and determine whether they cause failures in dental implants and …

Background: The effects of cyclooxygenase (COX) inhibition on fracture healing are
insufficiently documented, and the aim of this study was to evaluate the effects of nonspecific …

Critical-size bone defects after compound fractures, infection, or tumor resection are
challenging to treat. The same is true for fractures in patients with impaired bone healing …

ABSTRACT GαS, the stimulatory G protein α‐subunit that raises intracellular cAMP levels by
activating adenylyl cyclase, plays a vital role in bone development, maintenance, and …

Background Early mobilization post-total knee arthroplasty (TKA) significantly affects patient
outcomes. While parecoxib is known to reduce postoperative pain and morphine use with a …