Phospholipase A2 Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …
The expanding superfamily of phospholipase A2 enzymes: classification and characterization
DA Six, EA Dennis - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2000 - Elsevier
The phospholipase A2 (PLA2) superfamily consists of a broad range of enzymes defined by
their ability to catalyze the hydrolysis of the middle (sn-2) ester bond of substrate …
their ability to catalyze the hydrolysis of the middle (sn-2) ester bond of substrate …
Recent progress in phospholipase A2 research: from cells to animals to humans
M Murakami, Y Taketomi, Y Miki, H Sato… - Progress in lipid …, 2011 - Elsevier
Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …
related enzymes, which are subdivided into several classes including low-molecular-weight …
Membrane-protein interactions in cell signaling and membrane trafficking
W Cho, RV Stahelin - Annu. Rev. Biophys. Biomol. Struct., 2005 - annualreviews.org
▪ Abstract Research in the past decade has revealed that many cytosolic proteins are
recruited to different cellular membranes to form protein-protein and lipid-protein interactions …
recruited to different cellular membranes to form protein-protein and lipid-protein interactions …
A viral phospholipase A2 is required for parvovirus infectivity
Z Zádori, J Szelei, MC Lacoste, Y Li, S Gariépy… - Developmental cell, 2001 - cell.com
Sequence analysis revealed phospholipase A 2 (PLA 2) motifs in capsid proteins of
parvoviruses. Although PLA 2 activity is not known to exist in viruses, putative PLA 2 s from …
parvoviruses. Although PLA 2 activity is not known to exist in viruses, putative PLA 2 s from …
Phospholipase A2
M Murakami, I Kudo - The journal of biochemistry, 2002 - academic.oup.com
Phospholipase A2 (PLA2 catalyzes the hydrolysis of the sn-2 position of membrans
glyerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including …
glyerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including …
Phospholipase A2 enzymes
I Kudo, M Murakami - Prostaglandins & other lipid mediators, 2002 - Elsevier
Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane
glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including …
glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including …
Biochemistry and Physiology of Mammalian Secreted Phospholipases A2
Phospholipases A2 (PLA2s) are esterases that hydrolyze the sn-2 ester of
glycerophospholipids and constitute one of the largest families of lipid hydrolyzing enzymes …
glycerophospholipids and constitute one of the largest families of lipid hydrolyzing enzymes …
A new era of secreted phospholipase A2
M Murakami, H Sato, Y Miki, K Yamamoto… - Journal of lipid …, 2015 - ASBMB
Among more than 30 members of the phospholipase A 2 (PLA 2) superfamily, secreted PLA
2 (sPLA 2) enzymes represent the largest family, being Ca 2+-dependent low-molecular …
2 (sPLA 2) enzymes represent the largest family, being Ca 2+-dependent low-molecular …
Phospholipase A2 Biochemistry
JE Burke, EA Dennis - Cardiovascular drugs and therapy, 2009 - Springer
Abstract The phospholipase A 2 (PLA 2) superfamily consists of many different groups of
enzymes that catalyze the hydrolysis of the sn-2 ester bond in a variety of different …
enzymes that catalyze the hydrolysis of the sn-2 ester bond in a variety of different …