Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential

X Ding, L Gao, Z Han, S Eleuteri, W Shi, Y Shen… - Ageing research …, 2023 - Elsevier
Parkinson's Disease (PD) is characterized by the progressive loss of dopaminergic neurons
in the substantia nigra (SN), leading to motor and non-motor symptoms. While the exact …

Disorders of human coenzyme Q10 metabolism: an overview

I Hargreaves, RA Heaton, D Mantle - International journal of molecular …, 2020 - mdpi.com
Coenzyme Q10 (CoQ10) has a number of vital functions in all cells, both mitochondrial and
extramitochondrial. In addition to its key role in mitochondrial oxidative phosphorylation …

Coenzyme Q10 Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases

FM Gutierrez-Mariscal, AP Arenas-de Larriva… - International journal of …, 2020 - mdpi.com
Apart from its main function in the mitochondria as a key element in electron transport,
Coenzyme Q10 (CoQ10) has been described as having multiple functions, such as oxidant …

Nutraceutical approach to non-alcoholic fatty liver disease (NAFLD): the available clinical evidence

AFG Cicero, A Colletti, S Bellentani - Nutrients, 2018 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a clinical condition characterized by lipid
infiltration of the liver, highly prevalent in the general population affecting 25% of adults, with …

[HTML][HTML] Nutraceutical approaches to non-alcoholic fatty liver disease (NAFLD): A position paper from the International Lipid Expert Panel (ILEP)

M Rizzo, A Colletti, PE Penson, N Katsiki… - Pharmacological …, 2023 - Elsevier
Abstract Non-Alcoholic Fatty Liver Disease (NAFLD) is a common condition affecting around
10–25% of the general adult population, 15% of children, and even> 50% of individuals who …

Coenzyme Q10: Clinical Applications beyond Cardiovascular Diseases

L Testai, A Martelli, L Flori, AFG Cicero, A Colletti - Nutrients, 2021 - mdpi.com
Coenzyme Q10 (CoQ10) is an essential cofactor in oxidative phosphorylation (OXPHOS),
present in mitochondria and cell membranes in reduced and oxidized forms. Acting as an …

[HTML][HTML] Coenzyme Q10 supplementation–In ageing and disease

J Aaseth, J Alexander, U Alehagen - Mechanisms of Ageing and …, 2021 - Elsevier
Abstract Coenzyme Q 10 (CoQ 10) is an essential component of the mitochondrial electron
transport chain. It is also an antioxidant in cellular membranes and lipoproteins. All cells …

Bioavailability of Coenzyme Q10: An Overview of the Absorption Process and Subsequent Metabolism

D Mantle, A Dybring - Antioxidants, 2020 - mdpi.com
A lack of understanding of the processes determining the absorption and subsequent
metabolism of coenzyme Q10 (CoQ10) has resulted in some manufacturers' making …

[HTML][HTML] Coenzyme Q10: Clinical applications in cardiovascular diseases

A Martelli, L Testai, A Colletti, AFG Cicero - Antioxidants, 2020 - mdpi.com
Coenzyme Q 10 (CoQ 10) is a ubiquitous factor present in cell membranes and
mitochondria, both in its reduced (ubiquinol) and oxidized (ubiquinone) forms. Its levels are …

CoQ10 and aging

IP Barcelos, RH Haas - Biology, 2019 - mdpi.com
The aging process includes impairment in mitochondrial function, a reduction in anti-oxidant
activity, and an increase in oxidative stress, marked by an increase in reactive oxygen …