Zinc-based biodegradable materials for orthopaedic internal fixation

Y Liu, T Du, A Qiao, Y Mu, H Yang - Journal of functional biomaterials, 2022 - mdpi.com
Traditional inert materials used in internal fixation have caused many complications and
generally require removal with secondary surgeries. Biodegradable materials, such as …

A model industrial workhorse: Bacillus subtilis strain 168 and its genome after a quarter of a century

E Bremer, A Calteau, A Danchin… - Microbial …, 2023 - Wiley Online Library
The vast majority of genomic sequences are automatically annotated using various software
programs. The accuracy of these annotations depends heavily on the very few manual …

An iron–sulfur cluster in the zinc-binding domain of the SARS-CoV-2 helicase modulates its RNA-binding and-unwinding activities

N Maio, MK Raza, Y Li, DL Zhang… - Proceedings of the …, 2023 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
COVID-19, uses an RNA-dependent RNA polymerase along with several accessory factors …

Disruption of Zinc Homeostasis by a Novel Platinum (IV)‐Terthiophene Complex for Antitumor Immunity

X Su, B Liu, WJ Wang, K Peng, BB Liang… - Angewandte …, 2023 - Wiley Online Library
Zinc homeostatic medicine is of great potential for cancer chemo‐immunotherapy; however,
there are few reports on antitumor compounds that can trigger Zn2+‐mediated immune …

NAC controls cotranslational N-terminal methionine excision in eukaryotes

M Gamerdinger, M Jia, R Schloemer, L Rabl… - Science, 2023 - science.org
N-terminal methionine excision from newly synthesized proteins, catalyzed cotranslationally
by methionine aminopeptidases (METAPs), is an essential and universally conserved …

The elements of life: A biocentric tour of the periodic table

KA Remick, JD Helmann - Advances in microbial physiology, 2023 - Elsevier
Living systems are built from a small subset of the atomic elements, including the bulk
macronutrients (C, H, N, O, P, S) and ions (Mg, K, Na, Ca) together with a small but variable …

TerC proteins function during protein secretion to metalate exoenzymes

B He, AJ Sachla, JD Helmann - Nature Communications, 2023 - nature.com
Cytosolic metalloenzymes acquire metals from buffered intracellular pools. How exported
metalloenzymes are appropriately metalated is less clear. We provide evidence that TerC …

Maternal serum zinc level is associated with risk of preeclampsia: a systematic review and meta-analysis

S Jin, C Hu, Y Zheng - Frontiers in Public Health, 2022 - frontiersin.org
Background Preeclampsia (PE) is a multi-organ syndrome that onsets in the second half of
pregnancy. It is the second leading cause of maternal death globally. The homeostasis of …

Moving metals: How microbes deliver metal cofactors to metalloproteins

DE Kunkle, EP Skaar - Molecular Microbiology, 2023 - Wiley Online Library
First row d‐block metal ions serve as vital cofactors for numerous essential enzymes and are
therefore required nutrients for all forms of life. Despite this requirement, excess free …

Zinc and iron dynamics in human islet amyloid polypeptide-induced diabetes mouse model

A Fukunaka, M Shimura, T Ichinose, OB Pereye… - Scientific Reports, 2023 - nature.com
Metal homeostasis is tightly regulated in cells and organisms, and its disturbance is
frequently observed in some diseases such as neurodegenerative diseases and metabolic …