Drosophila as an In Vivo Model for Human Neurodegenerative Disease

L McGurk, A Berson, NM Bonini - Genetics, 2015 - academic.oup.com
With the increase in the ageing population, neurodegenerative disease is devastating to
families and poses a huge burden on society. The brain and spinal cord are extraordinarily …

How to turn an organism into a model organism in 10 'easy'steps

BJ Matthews, LB Vosshall - Journal of Experimental Biology, 2020 - journals.biologists.com
Many of the major biological discoveries of the 20th century were made using just six
species: Escherichia coli bacteria, Saccharomyces cerevisiae and Schizosaccharomyces …

[HTML][HTML] Non-canonical odor coding in the mosquito

M Herre, OV Goldman, TC Lu, G Caballero-Vidal, Y Qi… - Cell, 2022 - cell.com
Aedes aegypti mosquitoes are a persistent human foe, transmitting arboviruses including
dengue when they feed on human blood. Mosquitoes are intensely attracted to body odor …

α-synuclein induces mitochondrial dysfunction through spectrin and the actin cytoskeleton

DG Ordonez, MK Lee, MB Feany - Neuron, 2018 - cell.com
Genetics and neuropathology strongly link α-synuclein aggregation and neurotoxicity to the
pathogenesis of Parkinson's disease and related α-synucleinopathies. Here we describe a …

Plug-and-play genetic access to drosophila cell types using exchangeable exon cassettes

F Diao, H Ironfield, H Luan, F Diao, WC Shropshire… - Cell reports, 2015 - cell.com
Genetically encoded effectors are important tools for probing cellular function in living
animals, but improved methods for directing their expression to specific cell types are …

Cholinergic neurons trigger epithelial Ca2+ currents to heal the gut

A Petsakou, Y Liu, Y Liu, A Comjean, Y Hu, N Perrimon - Nature, 2023 - nature.com
A fundamental and unresolved question in regenerative biology is how tissues return to
homeostasis after injury. Answering this question is essential for understanding the …

Sensory discrimination of blood and floral nectar by Aedes aegypti mosquitoes

V Jové, Z Gong, FJH Hol, Z Zhao, TR Sorrells… - Neuron, 2020 - cell.com
Blood-feeding mosquitoes survive by feeding on nectar for metabolic energy but require a
blood meal to develop eggs. Aedes aegypti females must accurately discriminate blood and …

Modular synthetic biology toolkit for filamentous fungi

L Mózsik, C Pohl, V Meyer, RAL Bovenberg… - ACS Synthetic …, 2021 - ACS Publications
Filamentous fungi are highly productive cell factories, often used in industry for the
production of enzymes and small bioactive compounds. Recent years have seen an …

Imaging cell lineage with a synthetic digital recording system

KHK Chow, MW Budde, AA Granados, M Cabrera… - Science, 2021 - science.org
INTRODUCTION Cell lineage plays pivotal roles in cell fate determination in development,
homeostasis, and disease. The ability to visualize cell lineage relationships directly within …

Organization of olfactory centres in the malaria mosquito Anopheles gambiae

O Riabinina, D Task, E Marr, CC Lin, R Alford… - Nature …, 2016 - nature.com
Mosquitoes are vectors for multiple infectious human diseases and use a variety of sensory
cues (olfactory, temperature, humidity and visual) to locate a human host. A comprehensive …