Cannabinoid treatments in epilepsy and seizure disorders

O Devinsky, NA Jones, MO Cunningham… - Physiological …, 2024 - journals.physiology.org
Cannabis has been used to treat convulsions and other disorders since ancient times. In the
last few decades, preclinical animal studies and clinical investigations have established the …

Zebrafish as a robust preclinical platform for screening plant-derived drugs with anticonvulsant properties—a review

B Knap, D Nieoczym, U Kundap… - Frontiers in Molecular …, 2023 - frontiersin.org
Traditionally, selected plant sources have been explored for medicines to treat convulsions.
This continues today, especially in countries with low-income rates and poor medical …

Individually tailored dosage regimen of full-spectrum Cannabis extracts for autistic core and comorbid symptoms: a real-life report of multi-symptomatic benefits

PSS Montagner, W Medeiros, LCR da Silva… - Frontiers in …, 2023 - frontiersin.org
Autism Spectrum Disorders (ASD) may significantly impact the well-being of patients and
their families. The therapeutic use of cannabis for ASD has gained interest due to its …

Antiseizure effects of cannabidiol leading to increased peroxisome proliferator-activated receptor gamma levels in the hippocampal CA3 subfield of epileptic rats

AM Costa, F Russo, L Senn, D Ibatici, G Cannazza… - Pharmaceuticals, 2022 - mdpi.com
We evaluated the effects of cannabidiol (CBD) on seizures and peroxisome proliferator-
activated receptor gamma (PPARγ) levels in an animal model of temporal lobe epilepsy …

Cannabidiol‐rich non‐psychotropic Cannabis sativa L. oils attenuate peripheral neuropathy symptoms by regulation of CB2‐mediated microglial neuroinflammation

V Borgonetti, L Anceschi, V Brighenti… - Phytotherapy …, 2023 - Wiley Online Library
Neuropathic pain (NP) is a chronic disease that affects the normal quality of life of patients.
To date, the therapies available are only symptomatic and they are unable to reduce the …

Shared etiology in autism spectrum disorder and epilepsy with functional disability

A Zahra, YF Wang, Q Wang, J Wu - Behavioural Neurology, 2022 - Wiley Online Library
Autism spectrum disorders and epilepsies are heterogeneous human disorders that have
miscellaneous etiologies and pathophysiology. There is considerable risk of frequent …

Application of experimental design in HPLC method optimisation for the simultaneous determination of multiple bioactive cannabinoids

C Durante, L Anceschi, V Brighenti, C Caroli… - … of Pharmaceutical and …, 2022 - Elsevier
The scientific interest in Cannabis sativa L. analysis has been rapidly increasing in recent
years, especially for what concerns cannabinoids, plant secondary metabolites which are …

Advances and challenges of cannabidiol as an anti-seizure strategy: preclinical evidence

C Zavala-Tecuapetla, H Luna-Munguia… - International Journal of …, 2022 - mdpi.com
The use of Cannabis for medicinal purposes has been documented since ancient times,
where one of its principal cannabinoids extracted from Cannabis sativa, cannabidiol (CBD) …

Effects of Cannabis on Glutamatergic Neurotransmission: The Interplay between Cannabinoids and Glutamate

KU Chowdhury, ME Holden, MT Wiley… - Cells, 2024 - mdpi.com
There has been a significant increase in the consumption of cannabis for both recreational
and medicinal purposes in recent years, and its use can have long-term consequences on …

[HTML][HTML] Phytocannabinoids: Pharmacological effects, biomedical applications, and worldwide prospection

ALG de Brito Siqueira, PVV Cremasco, JO Bahú… - Journal of Traditional …, 2023 - Elsevier
Scientific evidence exists about the association between neurological diseases (ie,
Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), multiple …