Insights into the chemistry and therapeutic potential of furanones: A versatile pharmacophore

A Husain, SA Khan, F Iram, MA Iqbal, M Asif - European Journal of …, 2019 - Elsevier
Furanone, a five-membered heteroaromatic ring containing oxygen atom, is of immense
pharmaceutical importance. Presence of this nucleus in biologically active compounds of …

The current status of O‐heterocycles: A synthetic and medicinal overview

PK Singh, O Silakari - ChemMedChem, 2018 - Wiley Online Library
O‐Heterocycles have been explored in the field of medicinal chemistry for a long time, but
their significance has not been duly recognised and they are often shunned in favour of N …

Solvent polarity, structural and electronic properties with different solvents and biological studies of 3, 3, 5-triphenylfuran-2 (3H)-one-cancers of the blood cells

SC Parakkal, R Datta, A Saral, S Muthu, A Irfan… - Journal of Molecular …, 2022 - Elsevier
The current work comprises synthesis, characterization and computational evaluation on 3,
3, 5-triphenylfuran-2 (3H)-one with density functional theory (DFT) as the underlying …

Quinoline derivatives with potential activity against multidrug‐resistant tuberculosis

B Liu, F Li, T Zhou, XQ Tang… - Journal of heterocyclic …, 2018 - Wiley Online Library
Tuberculosis (TB), which affects primarily the lungs (pulmonary TB) apart from other vital
organs, is a life‐threatening chronic deadliest infectious disease caused by members of …

Antimicrobial and Biofilm-Preventing Activity of l-Borneol Possessing 2(5H)-Furanone Derivative F131 against S. aureusC. albicans Mixed Cultures

R Sulaiman, E Trizna, A Kolesnikova… - Pathogens, 2022 - mdpi.com
Candida albicans and Staphylococcus aureus are human pathogens that are able to form
mixed biofilms on the surface of mucous membranes, implants and catheters. In biofilms …

Butyrolactone-I from Coral-Derived Fungus Aspergillus terreus Attenuates Neuro-Inflammatory Response via Suppression of NF-κB Pathway in BV-2 Cells

YY Zhang, Y Zhang, YB Yao, XL Lei, ZJ Qian - Marine Drugs, 2018 - mdpi.com
Butyrolactone-I (ZB5-1) from the coral-derived fungus Aspergillus terreus was investigated in
this study to estimate its anti-neuroinflammatory effects on lipopolysaccharide (LPS)-induced …

Unraveling the Molecular Mechanism of Selective Antimicrobial Activity of 2(5H)-Furanone Derivative against Staphylococcus aureus

IS Sharafutdinov, AS Pavlova, FS Akhatova… - International Journal of …, 2019 - mdpi.com
Staphylococcus aureus causes various infectious diseases, from skin impetigo to life-
threatening bacteremia and sepsis, thus appearing an important target for antimicrobial …

Assessment of tuberculosis drug efficacy using preclinical animal models and in vitro predictive techniques

HFM Abdelaal, BJ Berube, BK Podell… - npj Antimicrobials and …, 2024 - nature.com
Abstract Tuberculosis (TB) killed approximately 1.3 million people in 2022 and remains a
leading cause of death from the bacteria Mycobacterium tuberculosis (M. tb); this number of …

Bis‐2(5H)‐furanone derivatives as new anticancer agents: Design, synthesis, biological evaluation, and mechanism studies

YC Wu, L Cao, WJ Mei, HQ Wu, SH Luo… - Chemical Biology & …, 2018 - Wiley Online Library
New bis‐2 (5H)‐furanone derivatives containing a benzidine core were synthesized via a
one‐step transition‐metal‐free reaction of benzidine with 5‐substituted 3, 4‐dihalo‐2 (5H) …

[HTML][HTML] 3,4-Dihalo-5-hydroxy-2(5H)-furanones: Highly Reactive Small Molecules

K Żurawska, A Byczek-Wyrostek, A Kasprzycka… - Molecules, 2024 - mdpi.com
3, 4-Dichloro-5-hydroxy-2 (5 H)-furanone and its dibromo analog are highly reactive
molecules. Both are members of the 2 (5 H)-furanone family, which are important as …