Innate immunity: the first line of defense against SARS-CoV-2
MS Diamond, TD Kanneganti - Nature immunology, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial morbidity …
respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial morbidity …
SARS-CoV-2, COVID-19 and the aging immune system
JM Bartleson, D Radenkovic, AJ Covarrubias… - Nature aging, 2021 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic is a global health threat with
particular risk for severe disease and death in older adults and in adults with age-related …
particular risk for severe disease and death in older adults and in adults with age-related …
Inflammasome activation at the crux of severe COVID-19
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly …
(SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly …
Immune response in COVID-19: what is next?
Abstract The coronavirus disease 2019 (COVID-19) has been a global pandemic for more
than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A …
than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A …
Innate immunological pathways in COVID-19 pathogenesis
SR Paludan, TH Mogensen - Science immunology, 2022 - science.org
Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound
dysregulation of the innate immune system. This knowledge has emerged from the large …
dysregulation of the innate immune system. This knowledge has emerged from the large …
Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells
R Planès, M Pinilla, K Santoni, A Hessel, C Passemar… - Molecular cell, 2022 - cell.com
Inflammation observed in SARS-CoV-2-infected patients suggests that inflammasomes,
proinflammatory intracellular complexes, regulate various steps of infection. Lung epithelial …
proinflammatory intracellular complexes, regulate various steps of infection. Lung epithelial …
Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice
J Zeng, X Xie, XL Feng, L Xu, JB Han, D Yu, QC Zou… - …, 2022 - thelancet.com
Summary Background The Coronavirus Disease 2019 (COVID-19) pandemic has been a
great threat to global public health since 2020. Although the advance on vaccine …
great threat to global public health since 2020. Although the advance on vaccine …
Pyroptosis and its role in autoimmune disease: a potential therapeutic target
R You, X He, Z Zeng, Y Zhan, Y Xiao… - Frontiers in …, 2022 - frontiersin.org
Autoimmune diseases are a group of heterogeneous diseases with diverse clinical
manifestations that can be divided into systemic and organ-specific. The common etiology of …
manifestations that can be divided into systemic and organ-specific. The common etiology of …
Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19
AK Maher, KL Burnham, EM Jones, MMH Tan… - Nature …, 2022 - nature.com
Although alterations in myeloid cells have been observed in COVID-19, the specific
underlying mechanisms are not completely understood. Here, we examine the function of …
underlying mechanisms are not completely understood. Here, we examine the function of …
The evolution of regulated cell death pathways in animals and their evasion by pathogens
B Tummers, DR Green - Physiological reviews, 2022 - journals.physiology.org
The coevolution of host-pathogen interactions underlies many human physiological traits
associated with protection from or susceptibility to infections. Among the mechanisms that …
associated with protection from or susceptibility to infections. Among the mechanisms that …