The COVID-19 pandemic has a significant impact on public health and the estimated
number of excess deaths may be more than three times higher than documented in official …

Abstract Coronavirus disease 2019 (COVID-19) is currently considered a complex systemic
infectious and inflammatory disease, determined by the infection with severe acute …

The existence of a local renin-an-giotensin system (RAS) specific to the hematopoietic bone
marrow (BM) microenvironment had been proposed two decades ago. Most of the RAS …

Despite the availability of various treatment protocols, response to therapy in patients with
Acute Myeloid Leukemia (AML) remains largely unpredictable. Transcriptomic profiling …

Abstract Introduction Coronavirus disease 2019 (COVID-19) may present with
extrapulmonary manifestations, including hematologic changes. Previous studies suggest …

The locally active ligand peptides, mediators, receptors and signalling pathways of the
haematopoietic BM (bone marrow) autocrine/paracrine RAS (renin–angiotensin system) …

The local haematopoietic bone marrow (BM) renin—angiotensin system (RAS) mediates
pathobiological alterations of haematopoiesis in an autocrine/paracrine/intracrine fashion …

Clinical treatment of acute myeloid leukemia (AML) largely relies on intensive
chemotherapy. However, the application of chemotherapy is often hindered by cardiotoxicity …

Classic Hodgkin lymphoma (CHL) is a highly curable disease, even in advanced stages.
Controversy remains over whether bone involvement negatively affects overall and …

Introduction: Acute myeloid leukemia (AML) is an aggressive malignancy, caused by the
accumulation of immature leukemic blasts in blood and bone marrow. There is a relatively …