We resolve the three-dimensional, nanoscale locations of single-molecule analytes within
commercial stationary phase materials using highly inclined and laminated optical sheet …

Surface morphology, in addition to hydrophobic and electrostatic effects, can alter how
proteins interact with solid surfaces. Understanding the heterogeneous dynamics of protein …

Polyamidamine (PAMAM) dendrimer-functionalized hydrothermal nanosized carbonaceous
spheres (HNCSs) were prepared and utilized as latexes for agglomerated anion exchange …

The rapid rise of biological pharmaceuticals motivates a need for both predictive models and
better materials for separations. Physical chemists now have the tools to deliver on an effort …

Single-molecule localization microscopy (SMLM) has revolutionized our ability to visualize
cellular structures, offering unprecedented detail. However, the intricate biophysical …

In this study, the interaction of crebanine, an isoquinoline alkaloid, with immunoglobulin G
(IgG) was evaluated. Subsequently, the anticancer effects of crebanine in MCF-7 breast …

Chemical separations are costly in terms of energy, time, and money. Separation methods
are optimized with inefficient trial-and-error approaches that lack insight into the molecular …

Ion-exchange chromatography (IEX) is commonly used as a purification step during
biomanufacturing of therapeutic biomolecules. Recent studies have shown evidence of …

Over the last two decades the pharmaceutical industry has been dynamic, moving away
from traditional small molecules towards protein-based drugs, also called biologics. 1 Figure …

Over the last decade the pharmaceutical industry has been experiencing a scientific
revolution, resulting in more biological-based therapeutics, also called biologics. Biologics …