Genetics and epigenetics of primary Sjögren syndrome: implications for future therapies

GE Thorlacius, A Björk… - Nature Reviews …, 2023 - nature.com
In primary Sjögren syndrome (pSS), chronic inflammation of exocrine glands results in tissue
destruction and sicca symptoms, primarily of the mouth and eyes. Fatigue, arthralgia and …

[PDF][PDF] Sjögren's syndrome: one year in review 2022

V Manfrè, LG Chatzis, G Cafaro, S Fonzetti… - Clin Exp …, 2022 - clinexprheumatol.org
Primary Sjögren's syndrome (pSS) is a complex disabling systemic autoimmune disorder.
The hallmark of pSS is the T-cell-mediated hyperactivation of B-cells, evolving from …

The role of virus infections in Sjögren's syndrome

M Maslinska, K Kostyra-Grabczak - Frontiers in Immunology, 2022 - frontiersin.org
Primary Sjögren's syndrome (pSS) is an autoimmune disease with a clinical picture of not
only mainly exocrine gland involvement, with dryness symptoms, but also internal organ and …

High-resolution DNA methylation screening of the major histocompatibility complex in multiple sclerosis

Q Ma, DG Augusto, G Montero-Martin… - Frontiers in …, 2023 - frontiersin.org
Background The HLA-DRB1 gene in the major histocompatibility complex (MHC) region in
chromosome 6p21 is the strongest genetic factor identified as influencing multiple sclerosis …

Genome-wide cross-disease analyses highlight causality and shared biological pathways of type 2 diabetes with gastrointestinal disorders

EO Adewuyi, T Porter, EK O'Brien, O Olaniru… - Communications …, 2024 - nature.com
Studies suggest links between diabetes and gastrointestinal (GI) traits; however, their
underlying biological mechanisms remain unclear. Here, we comprehensively assess the …

[HTML][HTML] Sjogren's syndrome: Everything you always wanted to know about genetic and epigenetic factors

C Perricone, L Bruno, G Cafaro, A Latini… - Autoimmunity …, 2024 - Elsevier
Primary Sjögren's syndrome (pSS) is a chronic, systemic autoimmune disease characterized
by a wide spectrum of glandular and extra-glandular features. Genetic and epigenetic …

Functional significance of DNA methylation: epigenetic insights into Sjögren's syndrome

Y Wang, F Riaz, W Wang, J Pu, Y Liang, Z Wu… - Frontiers in …, 2024 - frontiersin.org
Sjögren's syndrome (SjS) is a systemic, highly diverse, and chronic autoimmune disease
with a significant global prevalence. It is a complex condition that requires careful …

DNA methylation profiling of labial salivary gland tissues revealed hypomethylation of B-cell-related genes in primary Sjögren's syndrome

J Kabeerdoss, P Devarajalu, P Sandhya - Immunologic Research, 2024 - Springer
The objective of this epigenetic study was to investigate the cellular proportions based on
DNA methylation signatures and pathways of differentially methylated genes in labial …

Contribution of DNA methylation to the pathogenesis of sjögren's syndrome: A review

JR Guimarães, MC Coêlho, NFP de Oliveira - Autoimmunity, 2022 - Taylor & Francis
Sjögren's syndrome (SS) is a chronic systemic disease characterised by salivary and
lacrimal gland dysfunction with severe implications for the well-being of bearing individuals …

The Role of Sex and Hormones in Dry Eye Disease

ST Nøland - 2024 - duo.uio.no
Dry Eye Disease (DED) is the most prevalent condition in the field of ophthalmology. The
disease is characterized by symptoms such as itching, soreness, and, in severe cases …