Amyotrophic lateral sclerosis (ALS) is characterized by a progressive degeneration of upper
and lower motor neurons, resulting in fatal paralysis due to denervation of the muscle. Due …

In amyotrophic lateral sclerosis (ALS), abnormalities in motoneuronal excitability are seen in
early pathogenesis and throughout disease progression. Fully understanding motoneuron …

Key points Motoneuron soma size is a largely plastic property that is altered during
amyotrophic lateral sclerosis (ALS) progression. We report evidence of systematic spinal …

Amyotrophic lateral sclerosis (ALS) is an adult disease causing a progressive loss of upper
and lower motoneurons, muscle paralysis and early death. ALS has a poor prognosis of 3–5 …

Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by the
progressive degeneration of upper and lower motoneurons. Despite motoneuron death …

Early misfolded superoxide dismutase 1 (mfSOD1) accumulation, motor neuron (MN)
degeneration, and microgliosis are hallmark pathological features in SOD1G93A …

Disrupted copper availability in the central nervous system (CNS) is implicated as a
significant feature of the neurodegenerative disease amyotrophic lateral sclerosis (ALS) …

The complex neuronal networks of the spinal cord coordinate a wide variety of motor
functions, including walking, running, and voluntary and involuntary movements. This is …

An altered neuronal excitability of spinal motoneurones has consistently been implicated in
Amyotrophic Lateral Sclerosis (ALS) leading to several investigations of synaptic input to …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease preferentially affecting
motoneurones. Transgenic mouse models have been used to investigate the role of …