Abstract Development of topical bioactive formulations capable of overcoming the low
bioavailability of conventional eye drops is critically important for efficient management of …

Limbal stem cell deficiency (LSCD) is a debilitating ocular surface disease that eventuates
from a depleted or dysfunctional limbal epithelial stem cell (LESC) pool, resulting in corneal …

Corneal alkali burn (AB) injury is the most common sight-threatening injury that is highly
associated with oxidative stress, inflammation, apoptosis, angiogenesis, and cell deficiency …

Many signaling pathways, molecular and cellular actors which are critical for wound healing
have been implicated in cancer metastasis. These two conditions are a complex succession …

Eye injury due to alkali burn is a severe ocular trauma that can profoundly affect corneal
structure and function, including its biomechanical properties. Here, we assess the changes …

Corneal transparency relies on the precise arrangement and orientation of collagen fibrils,
made of mostly Type I and V collagen fibrils and proteoglycans (PGs). PGs are essential for …

Arterial hypertension (AH) leads to oxidative and inflammatory imbalance that contribute to
fibrosis development in many target organs. Here, we aimed to highlight the harmful effects …

Corneal scarring reduces corneal transparency, compromises vision, and is a major cause
of vision loss worldwide. Epidermal growth factor (EGF), which is the prototypic member of …

Purpose: Clinical data suggest that alcohol use is associated with the development of signs
and symptoms of dry eye disease. However, preclinical data investigating ocular toxicity …

Purpose Benzalkonium chloride (BAC) is commonly used as a preservative in ophthalmic
medications, despite its potential to induce chemical injury. Extensive research has …