Pfam, available via servers in the UK (http://pfam. sanger. ac. uk/) and the USA (http://pfam.
janelia. org/), is a widely used database of protein families, containing 14 831 manually …

Abstract The Database of Protein Disorder (DisProt, URL: https://disprot. org) provides
manually curated annotations of intrinsically disordered proteins from the literature. Here we …

Motivation Intrinsic disorder (ID) is established as an important feature of protein sequences.
Its use in proteome annotation is however hampered by the availability of many methods …

Intrinsic disorder is more abundant in eukaryotic than prokaryotic proteins. Methods
predicting intrinsic disorder are based on the amino acid sequence of a protein. Therefore …

To the Editor: Genome-scale CRISPR–Cas9 knockout libraries have emerged as powerful
tools for unbiased phenotypic screens1. These libraries contain a fixed number of Cas9 …

Motivation The earlier version of MobiDB-lite is currently used in large-scale proteome
annotation platforms to detect intrinsic disorder. However, new theoretical models allow for …

Abstract RepeatsDB (http://repeatsdb. bio. unipd. it/) is a database of annotated tandem
repeat protein structures. Tandem repeats pose a difficult problem for the analysis of protein …

Tandem repeats (TRs) are a major element of protein sequences in all domains of life. They
are particularly abundant in mammals, where by conservative estimates one in three …

Approaches for studying the evolution of globular proteins are now well established yet are
unsuitable for disordered sequences. Our understanding of the evolution of proteins …

Abstract RepeatsDB 2.0 (URL: http://repeatsdb. bio. unipd. it/) is an update of the database
of annotated tandem repeat protein structures. Repeat proteins are a widespread class of …