Langerhans cell histiocytosis (LCH), the most common histiocytic disorder, is characterized
by the accumulation of CD 1A+/CD 207+ mononuclear phagocytes within granulomatous …

Immune checkpoint inhibitors (ICIs) in combination with vascular endothelial growth factor
receptor (VEGFR) tyrosine kinase inhibitors (TKIs) have become a new standard of care in …

Abstract Lymphocyte activation gene-3 (LAG-3) is a CD4-related transmembrane protein
expressed by regulatory T cells that binds MHC II on APCs. It is shown in this study that …

The functions of dendritic cells (DCs) are tightly regulated such that protective immune
responses are elicited and unwanted immune responses are prevented. 1α25 …

Activation of immune cells to mediate an immune response is often triggered by potential
'danger'or 'stress' stimuli that the organism receives. Within the mitogen‐activated protein …

Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN) is a monocyte-derived
dendritic cell (MDDC)-specific lectin which participates in dendritic cell (DC) migration and …

Mitogen-activated protein kinase (MAPK) signaling cascade plays a pivotal role in the
activation of inflammatory cells. Recent findings revealed that the activity of p42/44 MAPK …

Cyclic diguanylate (c-di-GMP) is a bacterial intracellular signaling molecule. We have shown
that treatment with exogenous c-di-GMP inhibits Staphylococcus aureus infection in a …

The tyrosine kinase inhibitors sorafenib and sunitinib are approved for the treatment of
patients with malignant diseases. To analyze the possible use of these compounds in …

The immune system is ignorant or even unresponsive to most foreign proteins that are
injected in a soluble, deaggregated form, but when injected together with an immune …