The measurement of pain in animals is surprisingly complex, and remains a critical issue in
veterinary care and biomedical research. Based on the known utility of pain measurement …

Ensuring that laboratory rodent pain is well managed underpins the ethical acceptability of
working with these animals in research. Appropriate treatment of pain in laboratory rodents …

TRPA1 is a non‐selective cation channel expressed in mammalian peripheral pain
receptors, with a major role in chemonociception. TRPA1 has also been implicated in …

The ion channel TRPV1 is involved in a wide range of processes including nociception,
thermosensation and, more recently discovered, energy homeostasis. Tightly controlling …

In this article, we propose that differences in COVID-19 morbidity may be associated with
transient receptor potential ankyrin 1 (TRPA1) and/or transient receptor potential vanilloid 1 …

The transient receptor potential (TRP) superfamily of ion channels has garnered significant
attention by the pharmaceutical industry. In particular, TRP channels showing high levels of …

Transient receptor potential vanilloid subtype 1 (TRPV1) is a nonselective cationic channel
activated by painful stimuli such as capsaicin and noxious heat, and enriched in sensory …

Orofacial pain, including temporomandibular joint disorders pain, trigeminal neuralgia,
dental pain, and debilitating headaches, affects millions of Americans each year with …

Simple Summary The ability to identify and assess pain is paramount in animal research to
address the 'refinement'principle of the 3Rs (Reduction, Refinement, Replacement), satisfy …

Although pre-clinical models of pain are useful for defining relationships between biological
mechanisms and pain, common methods testing peripheral sensitivity do not translate to the …