Variation in the antibody response has been linked to differential outcomes in disease, and
suboptimal vaccine and therapeutic responsiveness, the determinants of which have not …

The role of estradiol (E2; an estrogen) in men needs to be more appreciated. In this review,
we address the clinical situations that allow the study of the clinical consequences of E2 …

Osteoporosis is a major clinical problem in many autoimmune diseases, including primary
biliary cholangitis (PBC), the most common autoimmune liver disease. Osteoporosis is a …

Objective Epidemiological and clinical studies have highlighted important roles for sex
hormones in the regulation of fat distribution and systemic metabolism. We investigated the …

An “old wives' tale” is a traditional truth not based on fact (1). The term is now an outmoded
and disrespectful vernacular about women (2). Many spurious truths about menopause have …

Background Low-density lipoprotein (LDL)-cholesterol is positively associated with
cardiovascular disease (CVD) and inversely associated with type 2 diabetes, which could …

Background High levels of estrogen are associated with increased risk of breast and
endometrial cancer and have been suggested to also play a role in the development of …

The aim of the study was directed at studying the sex-specific features of the correlation
between genome-wide association studies (GWAS)-noticeable polymorphisms and …

Background Oestrone, predominantly made in fat, is the main circulating oestrogen and
important for target tissue oestradiol production in women after menopause. The present …

Background Sex hormones are recognized to play a significant role in increasing bone
mineral density (BMD) and promoting bone maturation during adolescence. The purpose of …