The spliceosome removes introns from messenger RNA precursors (pre-mRNA). Decades
of biochemistry and genetics combined with recent structural studies of the spliceosome …

Nonsense-mediated mRNA decay (NMD) is one of the best characterized and most
evolutionarily conserved cellular quality control mechanisms. Although NMD was first found …

Abstract mRNA surveillance pathways are essential for accurate gene expression and to
maintain translation homeostasis, ensuring the production of fully functional proteins. Future …

RNA helicases comprise the largest family of enzymes involved in the metabolism of
mRNAs, the processing and fate of which rely on their packaging into messenger …

The exon junction complex (EJC) is deposited onto mRNAs following splicing and adopts a
unique structure, which can both stably bind to mRNAs and function as an anchor for diverse …

Mechanistic understanding of pre-mRNA splicing requires detailed structural information on
various states of the spliceosome. Here we report the cryo electron microscopy (cryo-EM) …

Precursor mRNA (pre-mRNA) splicing proceeds by two consecutive transesterification
reactions via a lariat–intron intermediate. Here we present the 3.8 Å cryo-electron …

Nonsense-mediated decay (NMD) was first described as a quality-control mechanism that
targets and rapidly degrades aberrant mRNAs carrying premature termination codons …

Nonsense-mediated mRNA decay (NMD) controls the quality of eukaryotic gene expression
and also degrades physiologic mRNAs. How NMD targets are identified is incompletely …

RNA helicases are critical regulators at the nexus of multiple pathways of RNA metabolism,
and in the complex cellular environment, tight spatial and temporal regulation of their activity …