Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

It is now established that airway smooth muscle (ASM) has roles in determining airway
structure and function, well beyond that as the major contractile element. Indeed, changes in …

Mesenchymal stromal cells (MSC) have been suggested to provide a suitable cellular
environment for in vitro expansion of haematopoietic stem and progenitor cells (HPC) from …

There are many situations of excessive production of reactive oxygen species (ROS) such
as radiation, ischemia/reperfusion (I/R), and inflammation. ROS contribute to and arises from …

Airway smooth muscle cell contraction is regulated by changes in intracellular Ca2+
concentration ([Ca2+] i) and the responsiveness of the airway smooth muscle cell to this …

CD38, a membrane protein expressed in airway smooth muscle (ASM) cells, plays a role in
cellular Ca2+ dynamics and ASM contractility. In human ASM (HASM) cells, TNF-α induces …

Contractility of airway smooth muscle requires elevation of intracellular calcium
concentration. Under resting conditions, airway smooth muscle cells maintain a relatively …

Human airway smooth muscle (HASM) cells are a rich source of inflammatory mediators that
may propagate the airway inflammatory responses. Recent studies from our laboratory and …

Airway diseases such as asthma involve increased airway smooth muscle (ASM)
contractility and remodelling via enhanced proliferation. Neurotrophins (NTs) such as brain …

Aging is a major risk factor for the leading causes of mortality, and the incidence of age-
related diseases including cardiovascular disease, kidney disease and metabolic disease …