Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the
United States with a median survival of< 6 mo and a dismal 5-yr survival rate of 3%–5%. The …

The oncogenic epithelial–mesenchymal transition (EMT) contributes to tumor progression in
various context-dependent ways, including increased metastatic potential, expansion of …

Pancreatic cancers arise predominantly from ductal epithelial cells of the exocrine pancreas
and are of the ductal adenocarcinoma histological subtype (PDAC). PDAC is an aggressive …

Mammalian cells that sustain oncogenic insults can invoke defensive programmes that
either halt their division or trigger their apoptosis, but these countermeasures must be finely …

Background The main cause of death in colorectal cancer patients is metastasis.
Accumulating evidences suggest that circRNA plays pivotal roles in cancer initiation and …

CtBP1 and CtBP2 are closely related and evolutionarily conserved transcriptional
corepressors. There is strong evidence linking CtBPs to tumorigenesis and tumor …

Anti-tumorigenic mechanisms mediated by the tumor suppressor p53, upon oncogenic
stresses, are our bodies' greatest weapons to battle against cancer onset and development …

The extracellular matrix (ECM), a principal component of pancreatic ductal adenocarcinoma
(PDA), is rich in fibrillar collagens that facilitate tumor cell survival and chemoresistance …

Detachment of epithelial cells from matrix or attachment to an inappropriate matrix engages
an apoptotic response known as anoikis, which prevents metastasis. Cellular sensitivity to …

ABSTRACT C-terminal Binding Proteins (CtBP) 1 and 2 are oncogenic transcriptional co-
regulators overexpressed in many cancer types, with their expression level correlating to …