Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

Two-component systems (TCSs) are a ubiquitous family of signal transduction pathways that
enable bacteria to sense and respond to physical, chemical, and biological stimuli outside …

Microbes can convert inexpensive renewable substrates to valuable metabolites by their
natural metabolic pathways. To maximize the productivity, the pathways yet require further …

Highlights•Metabolic cybergenetics promises unprecedented real-time control of
fermentations.•Optogenetic regulators make ideal actuators for metabolic cybergenetics.• …

Antibiotics are a key control mechanism for synthetic biology and microbiology. Resistance
genes are used to select desired cells and regulate bacterial populations, however their use …

Numerous photoreceptors and genetic circuits emerged over the past two decades and now
enable the light-dependent ie, optogenetic, regulation of gene expression in bacteria …

Progress in metabolic engineering and synthetic and systems biology has made
bioproduction an increasingly attractive and competitive strategy for synthesizing …

Optogenetics holds the promise of controlling biological processes with superb temporal
and spatial resolution at minimal perturbation. Although many of the light-reactive proteins …

Highlights•Polyketide precursor pathways are key biological entities for synthetic biology
driven strain improvement.•Diverse native and heterologous precursor pathways for …

Gut microbial metabolism is associated with host longevity. However, because it requires
direct manipulation of microbial metabolism in situ, establishing a causal link between these …