Our knowledge of proteoglycan biology has significantly expanded over the past decade
with the discovery of a host of new members of this multifunctional family leading to their …

Emerging evidence suggests that altered components and posttranslational modifications of
proteins in the extracellular matrix (ECM) may both initiate and drive disease progression …

Decorin, a prototype small leucine-rich proteoglycan, regulates a vast array of cellular
processes including collagen fibrillogenesis, wound repair, angiostasis, tumor growth, and …

An emerging body of evidence indicates that secreted proteoglycans act as signaling
molecules, in addition to their canonical function in maintaining and regulating the …

Increased attention is paid to the structural components of tissues. These components are
mostly collagens and various proteoglycans. Emerging evidence suggests that altered …

The small leucine‐rich proteoglycans (SLRPs) are involved in many aspects of mammalian
biology, both in health and disease. They are now being recognized as key signaling …

Promoter region hyermethylation and transcriptional silencing is a frequent cause of tumour
suppressor gene (TSG) inactivation in many types of human cancers. Functional epigenetic …

The small leucine-rich proteoglycans (SLRPs) are biologically active components of the
extracellular matrix (ECM), consisting of a protein core with leucine rich-repeat (LRR) motifs …

Decorin, the prototype member of the small leucine‐rich proteoglycans, resides in the tumor
microenvironment and affects the biology of various types of cancer by downregulating the …

The functional unit in skeletal muscle is the multinucleated myofiber, which is composed of
parallel arrays of microfibrils. The myofiber and sarco-mere structure of skeletal muscle are …