[HTML][HTML] Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs)

P Goettig, V Magdolen, H Brandstetter - Biochimie, 2010 - Elsevier
Including the true tissue kallikrein KLK1, kallikrein-related peptidases (KLKs) represent a
family of fifteen mammalian serine proteases. While the physiological roles of several KLKs …

Desquamative inflammatory vaginitis

O Reichman, J Sobel - Best practice & research Clinical obstetrics & …, 2014 - Elsevier
Desquamative inflammatory vaginitis (DIV) is an uncommon form of chronic purulent
vaginitis. It occurs mainly in Caucasians with a peak occurrence in the perimenopause …

Trappin‐2/Elafin: a novel innate anti‐human immunodeficiency virus‐1 molecule of the human female reproductive tract

M Ghosh, Z Shen, JV Fahey, S Cu‐Uvin, K Mayer… - …, 2010 - Wiley Online Library
Trappin‐2/Elafin is a serine protease inhibitor that plays a major role as an anti‐
inflammatory mediator at mucosal surfaces. In addition, Trappin‐2/Elafin has antibacterial …

Use of cervicovaginal fluid for the identification of biomarkers for pathologies of the female genital tract

G Zegels, GAA Van Raemdonck, WAA Tjalma… - Proteome science, 2010 - Springer
Cervicovaginal fluid has an important function in the homeostasis and immunity of the lower
female genital tract. Analysis of the cervicovaginal fluid proteome may therefore yield …

CCL20/MIP3α is a novel anti‐HIV‐1 molecule of the human female reproductive tract

M Ghosh, Z Shen, TM Schaefer… - American journal of …, 2009 - Wiley Online Library
Problem CCL20/MIP3α is a chemokine for immature dendritic cells as well as an
antibacterial against gram‐positive and gram‐negative bacteria. The role of CCL20/MIP3α …

The use of kallikrein-related peptidases as adjuvant prognostic markers in colorectal cancer

M Talieri, L Li, Y Zheng, DK Alexopoulou… - British journal of …, 2009 - nature.com
Several members of the human tissue kallikrein-related peptidase (KLK) family are
emerging cancer biomarkers. The aim of this study was to analyse the expression of a panel …

Kallikrein-related peptidase 12 hydrolyzes matricellular proteins of the CCN family and modifies interactions of CCN1 and CCN5 with growth factors

A Guillon-Munos, K Oikonomopoulou, N Michel… - Journal of biological …, 2011 - ASBMB
Kallikrein-related peptidases (KLKs) are an emerging group of secreted serine proteases
involved in several physiological and pathological processes. We used a degradomic …

KLK5 is associated with the radioresistance, aggression, and progression of cervical cancer

S Zhou, S Liu, G Tian, L Zhao, H Wang, Y Li… - Gynecologic …, 2022 - Elsevier
Objective The role of kallikrein-related peptidase 5 (KLK5) has been studied in several
diseases, including skin and ovarian cancers. However, its role in cervical cancer remains …

Human epididymis protein 4 and secretory leukocyte protease inhibitor in vaginal fluid: relation to vaginal components and bacterial composition

T Orfanelli, A Jayaram, G Doulaveris… - Reproductive …, 2014 - journals.sagepub.com
Human epididymis protein 4 (HE4) is a protease inhibitor and a recently identified serum
biomarker for ovarian cancer. Properties of HE4 in the genital tract of healthy women have …

Microbial and human transcriptome in vaginal fluid at midgestation: Association with spontaneous preterm delivery

T Wikström, S Abrahamsson… - Clinical and …, 2022 - Wiley Online Library
Background Intrauterine infection and inflammation caused by microbial transfer from the
vagina are believed to be important factors causing spontaneous preterm delivery (PTD) …