Antigen-specific T-cell responses induced by infection, transplantation, autoimmunity or
hypersensitivity are characterized by cells expressing biased profiles of T-cell receptors …

Antiviral CD8+ T cells respond to only a minute fraction of the potential peptide determinants
encoded by viral genomes. Immunogenic determinants can be ordered into highly …

Antigenic peptides recognized by virus-specific cytotoxic T lymphocytes (CTLs) are
presented by major histocompatibility complex (MHC; or human leukocyte antigen [HLA] in …

Positive selection in the thymus provides low-affinity T-cell receptor (TCR) engagement to
support the development of potentially useful self-major histocompatibility complex class I …

We encounter pathogens on a daily basis and our immune system has evolved to mount an
immune response following an infection. An interesting phenomenon that has evolved in …

Human Papillomavirus 16 (HPV-16) has been identified as the causative agent of 50% of
cervical cancers and many other HPV-associated tumors. The transforming potential/tumor …

The presentation of viral epitopes to cytotoxic T lymphocytes (CTLs) by swine leukocyte
antigen class I (SLA I) is crucial for swine immunity. To illustrate the structural basis of swine …

Abstract Ag-specific, CD8+ CTLs clear influenza A viruses from the lung via granzyme (Gzm)
and perforin-dependent mechanisms. Ex vivo analysis of perforin-Gzm mRNA profiles …

The immune system is constantly challenged, being required to protect the organism against
a wide variety of infectious pathogens and, at the same time, to avoid autoimmune disorders …

Influenza is one of the most common infectious diseases afflicting humans, particularly the
elderly. The murine model has been widely employed for investigation of immunity to …