State of the evidence 2017: an update on the connection between breast cancer and the environment

JM Gray, S Rasanayagam, C Engel, J Rizzo - Environmental Health, 2017 - Springer
Background In this review, we examine the continually expanding and increasingly
compelling data linking radiation and various chemicals in our environment to the current …

Role of the aryl hydrocarbon receptor in carcinogenesis and potential as a drug target

S Safe, SO Lee, UH Jin - Toxicological Sciences, 2013 - academic.oup.com
The aryl hydrocarbon receptor (AHR) is highly expressed in multiple organs and tissues,
and there is increasing evidence that the AHR plays an important role in cellular …

Cytochrome P450 1 family and cancers

RE Go, KA Hwang, KC Choi - The Journal of steroid biochemistry and …, 2015 - Elsevier
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor that
dimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT). This complex binds to …

Role of aryl hydrocarbon receptor in cancer

S Feng, Z Cao, X Wang - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2013 - Elsevier
Aryl hydrocarbon receptor (AHR), a cytosolic ligand-activated transcription factor, belongs to
the member of bHLH/PAS family of heterodimeric transcriptional regulators and is widely …

Endocrine disruptors and endometrial cancer: molecular mechanisms of action and clinical implications, a systematic review

D Caserta, MP De Marco, AR Besharat… - International Journal of …, 2022 - mdpi.com
It has been widely demonstrated that endocrine disruptors play a central role in various
physiopathological processes of human health. In the literature, various carcinogenic …

Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes

J Iqbal, L Sun, J Cao, T Yuen, P Lu… - Proceedings of the …, 2013 - National Acad Sciences
Smoking is a major risk factor for osteoporosis and fracture, but the mechanism through
which smoke causes bone loss remains unclear. Here, we show that the smoke toxins …

The aryl hydrocarbon receptor repressor–more than a simple feedback inhibitor of AhR signaling: clues for its role in inflammation and cancer

CFA Vogel, T Haarmann-Stemmann - Current opinion in toxicology, 2017 - Elsevier
The aryl hydrocarbon receptor repressor (AhRR) was first described as a specific
competitive repressor of aryl hydrocarbon receptor (AhR) activity based on its ability to …

[HTML][HTML] Regulation of the aryl hydrocarbon receptor in cancer and cancer stem cells of gynecological malignancies: An update on signaling pathways

L Therachiyil, OJ Hussein, S Uddin… - Seminars in Cancer …, 2022 - Elsevier
Gynecological malignancies are a female type of cancers that affects the reproductive
system. Cancer metastasis or recurrence mediated by cellular invasiveness occurs at …

Chemical activation of estrogen and aryl hydrocarbon receptor signaling pathways and their interaction in toxicology and metabolism

P Tarnow, T Tralau, A Luch - Expert opinion on drug metabolism & …, 2019 - Taylor & Francis
ABSTRACT Introduction: Estrogen receptors (ERs) and the arylhydrocarbon receptor (AHR)
are ligand-activated transcription factors that regulate the expression of genes involved in …

Coffee intake, cardiovascular disease and all-cause mortality: observational and Mendelian randomization analyses in 95 000–223 000 individuals

AT Nordestgaard… - International journal of …, 2016 - academic.oup.com
Background: Coffee has been associated with modestly lower risk of cardiovascular disease
and all-cause mortality in meta-analyses; however, it is unclear whether these are causal …