Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval

D Hwang, JD Ramsey, AV Kabanov - Advanced drug delivery reviews, 2020 - Elsevier
Over the last three decades, polymeric micelles have emerged as a highly promising drug
delivery platform for therapeutic compounds. Particularly, poorly soluble small molecules …

Poly (2-oxazoline) s based biomaterials: A comprehensive and critical update

T Lorson, MM Luebtow, E Wegener, MS Haider… - Biomaterials, 2018 - Elsevier
Abstract Poly (2-oxazoline) s have been investigated for decades as biomaterials.
Pioneering early work suggested that hydrophilic poly (2-oxazoline) s are comparable to …

Therapeutic protein–polymer conjugates: advancing beyond PEGylation

EM Pelegri-O'Day, EW Lin… - Journal of the American …, 2014 - ACS Publications
Protein–polymer conjugates are widely used as therapeutics. All Food and Drug
Administration (FDA)-approved protein conjugates are covalently linked to poly (ethylene …

The golden age: gold nanoparticles for biomedicine

EC Dreaden, AM Alkilany, X Huang… - Chemical Society …, 2012 - pubs.rsc.org
Gold nanoparticles have been used in biomedical applications since their first colloidal
syntheses more than three centuries ago. However, over the past two decades, their …

Poly (ethylene glycol) in drug delivery: pros and cons as well as potential alternatives

K Knop, R Hoogenboom, D Fischer… - Angewandte chemie …, 2010 - Wiley Online Library
Abstract Poly (ethylene glycol)(PEG) is the most used polymer and also the gold standard for
stealth polymers in the emerging field of polymer‐based drug delivery. The properties that …

The chemistry of poly (2-oxazoline) s

B Verbraeken, BD Monnery, K Lava… - European Polymer …, 2017 - Elsevier
As we celebrate the 50th birthday of the discovery of poly (2-alkyl/aryl-2-oxazoline) s (PAOx)
this year we see a research field that is rapidly expanding after some lesser academic …

On the biodegradability of polyethylene glycol, polypeptoids and poly (2-oxazoline) s

J Ulbricht, R Jordan, R Luxenhofer - Biomaterials, 2014 - Elsevier
Despite being the gold standard of hydrophilic biomaterials and well known sensitivity of
polyethylene glycol (PEG) against oxidative degradation, very little information on the …

Poly (2‐oxazoline) s: a polymer class with numerous potential applications

R Hoogenboom - Angewandte Chemie International Edition, 2009 - Wiley Online Library
The living cationic ring‐opening polymerization of 2‐oxazolines has been studied in great
detail since its discovery in 1966. The versatility of this living polymerization method allows …

Poly (2‐oxazoline) s as Polymer Therapeutics

R Luxenhofer, Y Han, A Schulz, J Tong… - Macromolecular …, 2012 - Wiley Online Library
Abstract Poly (2‐oxazoline) s (POx) are currently discussed as an upcoming polymer
platform for biomaterials design and especially for polymer therapeutics. POx meet specific …

Temperature responsive bio-compatible polymers based on poly (ethylene oxide) and poly (2-oxazoline) s

C Weber, R Hoogenboom, US Schubert - Progress in Polymer Science, 2012 - Elsevier
This review covers the LCST behavior of two important polymer classes in aqueous solution,
namely poly (2-oxazoline) s and systems whose thermo-responsiveness is based on their …