Glucuronidation: driving factors and their impact on glucuronide disposition
Glucuronidation is a well-recognized phase II metabolic pathway for a variety of chemicals
including drugs and endogenous substances. Although it is usually the secondary metabolic …
including drugs and endogenous substances. Although it is usually the secondary metabolic …
Radiolabeled absorption, distribution, metabolism, and excretion studies in drug development: why, when, and how?
N Penner, L Xu, C Prakash - Chemical research in toxicology, 2012 - ACS Publications
Absorption, distribution, metabolism, and excretion (ADME) studies are an integral part of
the comprehensive safety evaluation of a new molecular entity, and they represent a …
the comprehensive safety evaluation of a new molecular entity, and they represent a …
[HTML][HTML] In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors
M Benvenuto, L Masuelli, E De Smaele, M Fantini… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract Aberrant Hedgehog (Hh)/glioma-associated oncogene (GLI) signaling has been
implicated in cancer progression. Here, we analyzed GLI1, Sonic Hedgehog (Shh) and NF …
implicated in cancer progression. Here, we analyzed GLI1, Sonic Hedgehog (Shh) and NF …
Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo-and nanotherapy
Targeting the rich extracellular matrix of desmoplastic tumors has been successfully shown
to normalize collagen and hyaluronan levels and re-engineer intratumoral mechanical …
to normalize collagen and hyaluronan levels and re-engineer intratumoral mechanical …
Use of radioactive compounds and autoradiography to determine drug tissue distribution
EG Solon - Chemical research in toxicology, 2012 - ACS Publications
Radioactivity has been used in drug discovery and development for several decades
because it offers researchers a highly sensitive way to quantitatively assess the absorption …
because it offers researchers a highly sensitive way to quantitatively assess the absorption …
Discovery and preclinical development of vismodegib
SE Gould, JA Low, JC Marsters Jr… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: Vismodegib is the first Hedgehog (Hh) pathway inhibitor approved in the US for
the treatment of adults with metastatic or locally advanced basal cell carcinoma (BCC). It …
the treatment of adults with metastatic or locally advanced basal cell carcinoma (BCC). It …
Hedgehog signaling mediates woven bone formation and vascularization during stress fracture healing
Hedgehog (Hh) signaling is critical in developmental osteogenesis, and recent studies
suggest it may also play a role in regulating osteogenic gene expression in the post-natal …
suggest it may also play a role in regulating osteogenic gene expression in the post-natal …
A single dose mass balance study of the Hedgehog pathway inhibitor vismodegib (GDC-0449) in humans using accelerator mass spectrometry
RA Graham, BL Lum, G Morrison, I Chang… - Drug metabolism and …, 2011 - ASPET
Vismodegib (GDC-0449), a small-molecule Hedgehog pathway inhibitor, was well tolerated
in patients with solid tumors and showed promising efficacy in advanced basal cell …
in patients with solid tumors and showed promising efficacy in advanced basal cell …
[HTML][HTML] Skin cancer therapeutics: Nano-drug delivery vectors—present and beyond
Background Skin cancers are among the widely prevalent forms of cancer worldwide. The
increasing industrialization and accompanied environmental changes have further …
increasing industrialization and accompanied environmental changes have further …
Profile of vismodegib and its potential in the treatment of advanced basal cell carcinoma
Basal cell carcinoma (BCC) is the most common human malignancy. Recent advances in
our understanding of the critical biologic pathways implicated in the development and …
our understanding of the critical biologic pathways implicated in the development and …