The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology

RJ Grams, WL Santos, IR Scorei, A Abad-García… - Chemical …, 2024 - ACS Publications
Boron-containing compounds (BCC) have emerged as important pharmacophores. To date,
five BCC drugs (including boronic acids and boroles) have been approved by the FDA for …

The boron advantage: the evolution and diversification of boron's applications in medicinal chemistry

K Messner, B Vuong, GK Tranmer - Pharmaceuticals, 2022 - mdpi.com
In this review, the history of boron's early use in drugs, and the history of the use of boron
functional groups in medicinal chemistry applications are discussed. This includes …

Novel 2D MBenes—synthesis, structure, and biotechnological potential

M Jakubczak, A Szuplewska… - Advanced Functional …, 2021 - Wiley Online Library
Abstract 2D transition metal borides (MBenes) have emerged as promising post‐MXene
materials with potential application in various biotechnological fields. Although they possess …

Recent developments in the chemistry and biological applications of benzoxaboroles

A Adamczyk-Wozniak, KM Borys… - Chemical …, 2015 - ACS Publications
1. INTRODUCTION Benzoxaboroles, first obtained by Torssell in 1957, 1 remained
underestimated for a long time. The new beginning for these remarkable compounds took …

The taxonomy of covalent inhibitors

A Tuley, W Fast - Biochemistry, 2018 - ACS Publications
Covalent enzyme inhibitors are widely applied as biochemical tools and therapeutic agents.
As a complement to categorization of these inhibitors by reactive group or modification site …

Synthesis of biologically active boron-containing compounds

F Yang, M Zhu, J Zhang, H Zhou - MedChemComm, 2018 - pubs.rsc.org
Boron-containing compounds which possess unique and attractive properties have received
increasing attention from the pharmaceutical industry and academia recently. They have …

Injectable self-healing hydrogels based on boronate ester formation between hyaluronic acid partners modified with benzoxaborin derivatives and saccharides

T Figueiredo, J Jing, I Jeacomine, J Olsson… - …, 2019 - ACS Publications
We demonstrate here, for the first time, formation of injectable dynamic covalent hydrogels at
physiological pH using benzoxaborin-saccharide complexation as a reversible cross-linking …

The modern role of boron as a 'magic element'in biomedical science: chemistry perspective

S Chatterjee, NM Tripathi… - Chemical …, 2021 - pubs.rsc.org
Boron was misconstrued as a toxic element for animals, which retarded the growth of boron-
containing drug discovery in the last century. Nevertheless, modern applications of boronic …

Benzoxaborole compounds for therapeutic uses: a patent review (2010-2018)

A Nocentini, CT Supuran, JY Winum - Expert opinion on therapeutic …, 2018 - Taylor & Francis
Introduction: Benzoxaborole is a versatile boron-heterocyclic scaffold which has found in the
last 10 years a broad spectrum of applications in medicinal chemistry, due to its …

Boronic acid with high oxidative stability and utility in biological contexts

BJ Graham, IW Windsor, B Gold… - Proceedings of the …, 2021 - National Acad Sciences
Despite their desirable attributes, boronic acids have had a minimal impact in biological
contexts. A significant problem has been their oxidative instability. At physiological pH …