Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …

For many years, transcription factor Sp1 was viewed as a basal transcription factor and
relegated to a role in the regulation of so‐called housekeeping genes. Identification of Sp1's …

It has been shown that addition of fennel in the diets of domestic animals has positive and
beneficial effects on growth and meat production traits. Thus, the purpose of current study …

IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the
cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti …

BACKGROUND: Insulin-like growth factor 1 (IGF1) stimulates mitosis and inhibits apoptosis.
Some published results have shown an association between circulating IGF1 and breast …

Hydrogen sulfide (H 2 S) is the third gaseous signaling molecule that plays important roles
in cancer biological processes. Recent studies indicate that H 2 S has both pro-cancer and …

Insulin-like growth factor (IGF) signaling is fundamental for growth and survival. A large body
of evidence (laboratory, epidemiological, and clinical) implicates the exploitation of this …

Background: A major challenge in cancer chemotherapy has been developing safe and
clinically efficacious chemotherapeutic agents. With its low toxicity profile, curcumin …

Abstract 17β-Estradiol (E2) binds to the estrogen receptor (ER) to activate gene expression
or repression and this involves both genomic (nuclear) and non-genomic (extranuclear …

The evasion of anti-growth signaling is an important characteristic of cancer cells. In order to
continue to proliferate, cancer cells must somehow uncouple themselves from the many …