Reticular pseudodrusen: a critical phenotype in age-related macular degeneration

Z Wu, EL Fletcher, H Kumar, U Greferath… - Progress in retinal and …, 2022 - Elsevier
Reticular pseudodrusen (RPD), or subretinal drusenoid deposits (SDD), refer to distinct
lesions that occur in the subretinal space. Over the past three decades, their presence in …

A paradigm shift in imaging biomarkers in neovascular age-related macular degeneration

U Schmidt-Erfurth, SM Waldstein - Progress in Retinal and eye Research, 2016 - Elsevier
Neovascular age-related macular degeneration (AMD) has undergone substantial break-
throughs in diagnostic as well as therapeutic respect, with optical coherence tomography …

Tolerating subretinal fluid in neovascular age-related macular degeneration treated with ranibizumab using a treat-and-extend regimen: FLUID study 24-month results

RH Guymer, CM Markey, IL McAllister, MC Gillies… - Ophthalmology, 2019 - Elsevier
Purpose To test the hypothesis that tolerating some subretinal fluid (SRF) in patients with
neovascular age-related macular degeneration (nAMD) treated with ranibizumab using a …

[HTML][HTML] Real-world outcomes in patients with neovascular age-related macular degeneration treated with intravitreal vascular endothelial growth factor inhibitors

H Mehta, A Tufail, V Daien, AY Lee, V Nguyen… - Progress in retinal and …, 2018 - Elsevier
Clinical trials identified intravitreal vascular endothelial growth factor inhibitors (anti-VEGF
agents) have the potential to stabilise or even improve visual acuity outcomes in …

Age-related macular degeneration: pathophysiology, management, and future perspectives

R Flores, Â Carneiro, M Vieira, S Tenreiro… - Ophthalmologica, 2021 - karger.com
Among older adults, age-related macular degeneration (AMD) is a prevalent disabling
condition that begins as subtle visual disturbances and can progress to permanent loss of …

Emerging therapeutic strategies for unmet need in neovascular age-related macular degeneration

LM Khachigian, G Liew, KYC Teo, TY Wong… - Journal of Translational …, 2023 - Springer
Neovascular age-related macular degeneration (nAMD) is a major cause of visual
impairment and blindness. Anti-vascular endothelial growth factor (VEGF) agents, such as …

Genetics of age-related macular degeneration (AMD)

MM DeAngelis, LA Owen, MA Morrison… - Human molecular …, 2017 - academic.oup.com
Age-related macular degeneration (AMD) is a progressive blinding disease and represents
the leading cause of visual impairment in the aging population. AMD affects central vision …

VEGF regulates local inhibitory complement proteins in the eye and kidney

LS Keir, R Firth, L Aponik, D Feitelberg… - The Journal of …, 2017 - Am Soc Clin Investig
Outer retinal and renal glomerular functions rely on specialized vasculature maintained by
VEGF that is produced by neighboring epithelial cells, the retinal pigment epithelium (RPE) …

Cellular strategies for retinal repair by photoreceptor replacement

SA Jayakody, A Gonzalez-Cordero, RR Ali… - Progress in retinal and …, 2015 - Elsevier
Loss of photoreceptors due to retinal degeneration is a major cause of blindness in the
developed world. While no effective treatment is currently available, cell replacement …

Association of baseline characteristics and early vision response with 2-year vision outcomes in the Comparison of AMD Treatments Trials (CATT)

G Ying, MG Maguire, E Daniel, FL Ferris, GJ Jaffe… - Ophthalmology, 2015 - Elsevier
Purpose To evaluate the association of baseline characteristics and early visual acuity (VA)
response with visual outcomes at years 1 or 2 in the Comparison of Age-Related Macular …