Abstract Merlin (Moesin-ezrin-radixin-like protein, also known as schwannomin) is a tumor
suppressor protein encoded by the neurofibromatosis type 2 gene NF2. Loss of function …

Extracellular signal-regulated kinase (ERK) is a member of the mitogen-activated protein
kinase family of signaling molecules. ERK is predominantly found in two forms, ERK1 (p44) …

Cancer metastasis is the primary cause of morbidity and mortality in cancer as it remains the
most complicated, devastating, and enigmatic aspect of cancer. Several decades of …

Inactivation of the tumor suppressor NF2/merlin underlies neurofibromatosis type 2 (NF2)
and some sporadic tumors. Previous studies have established that merlin mediates contact …

Background: MicroRNA-224 (miR-224) and microRNA-452 (miR-452) are closely located on
the human chromosome Xq28 region. miR-224 functions as a tumour suppressor by …

Background Nanoparticles are being increasingly used in biomedical applications owing to
their unique physical and chemical properties and small size. However, their biophysical …

Abstract Neurofibromatosis type 2 (NF2), which encodes merlin (moesin-ezrin-radixin-like
protein), belongs to the band 4.1, ezrin, radixin, moesin (FERM) domain-containing 4.1 …

We performed additional mechanistic analyses to redefine neratinib biology and determined
the mechanisms by which the multi-kinase inhibitor neratinib interacted with the thymidylate …

For stem cell-based therapies, the fate and distribution of stem cells should be traced using
non-invasive or histological methods and a nanomaterial-based labelling agent. However …

Ectodomain cleavage (shedding) of transmembrane proteins by metalloproteases (MMP)
generates numerous essential signaling molecules, but its regulation is not totally …