Yeast Mec1, and its mammalian ortholog, Ataxia-Telangiectasia and Rad3-related, are giant protein kinases central to replication stress and double strand DNA break repair. Mec1 ATR …
J D'Souza, ID Hickson - DNA repair, 2024 - Elsevier
DNA replication ensures the complete and accurate duplication of the genome. The traditional approach to analysing perturbation of DNA replication is to use chemical …
Genomic instability is a hallmark of cancer that can be caused by various forms of DNA replication stress. Collision of the replication fork with obstacles ahead of the replication …