Induction of homologous recombination by site-specific replication stress

MK Triplett, MJ Johnson, LS Symington - DNA repair, 2024 - Elsevier
ABSTRACT DNA replication stress is one of the primary causes of genome instability. In
response to replication stress, cells can employ replication restart mechanisms that rely on …

[HTML][HTML] DNA repair Special Issue Cutting Edge Perspectives 2023 Phosphoregulation of the checkpoint kinase Mec1ATR

LA Yates, X Zhang - DNA repair, 2023 - Elsevier
Yeast Mec1, and its mammalian ortholog, Ataxia-Telangiectasia and Rad3-related, are giant
protein kinases central to replication stress and double strand DNA break repair. Mec1 ATR …

[HTML][HTML] Replication fork barriers to study site-specific DNA replication perturbation

J D'Souza, ID Hickson - DNA repair, 2024 - Elsevier
DNA replication ensures the complete and accurate duplication of the genome. The
traditional approach to analysing perturbation of DNA replication is to use chemical …

Investigating the Impact of Site-Specific Replication Stress on Homologous Recombination

MK Triplett - 2024 - search.proquest.com
Genomic instability is a hallmark of cancer that can be caused by various forms of DNA
replication stress. Collision of the replication fork with obstacles ahead of the replication …