[HTML][HTML] Impaired cholesterol metabolism, neurons, and neuropsychiatric disorders

SY Cheon - Experimental Neurobiology, 2023 - ncbi.nlm.nih.gov
Cholesterol metabolism plays an essential role in cellular functions (including as a
component of the plasma membrane, as an energy source, and in hormone production) …

Lipids in major depressive disorder: new kids on the block or old friends revisited?

AR van der Heijden, T Houben - Frontiers in Psychiatry, 2023 - frontiersin.org
Major depressive disorder (MDD) is a psychiatric mood disorder that results in substantial
functional impairment and is characterized by symptoms such as depressed mood …

[HTML][HTML] Gender-based differences in anxiety and depression following acute myocardial infarction

P Serpytis, P Navickas, L Lukaviciute… - Arquivos brasileiros de …, 2018 - SciELO Brasil
Background: Among patients with heart disease, depression and anxiety disorders are
highly prevalent and persistent. Both depression and anxiety play a significant role in …

Morus nigra and its major phenolic, syringic acid, have antidepressant-like and neuroprotective effects in mice

AP Dalmagro, A Camargo, ALB Zeni - Metabolic brain disease, 2017 - Springer
Depression is a disorder with a high incidence that has been increasing worldwide although
the pathophysiology remains unclear. Moreover, some studies revealed a higher …

Hypocholesterolemia is an independent risk factor for depression disorder and suicide attempt in Northern Mexican population

M Segoviano-Mendoza, M Cárdenas-de la Cruz… - BMC psychiatry, 2018 - Springer
Background Cholesterol has been associated as a risk factor for cardiovascular disease.
Recently, however, there is growing evidence about crucial requirement of neuron …

Factors associated with the risk of developing coronary artery disease in medicated patients with major depressive disorder

RCM Ho, AC Chua, BX Tran, CC Choo… - International journal of …, 2018 - mdpi.com
Background: The aim of this study was to identify factors associated with high Framingham
Risk Score (FRS) in medicated patients with major depressive disorder (MDD). Methods: We …

Are lipids possible markers of suicide behaviors?

A Kułak-Bejda, G Bejda, M Lech… - Journal of clinical …, 2021 - mdpi.com
Suicides and suicidal behaviors are very important causes of mortality and morbidity and
have become a serious global problem. More than 800,000 people die from suicide every …

Structural insights into GIRK2 channel modulation by cholesterol and PIP2

YK Mathiharan, IW Glaaser, Y Zhao, MJ Robertson… - Cell reports, 2021 - cell.com
G-protein-gated inwardly rectifying potassium (GIRK) channels are important for determining
neuronal excitability. In addition to G proteins, GIRK channels are potentiated by membrane …

[HTML][HTML] Impaired adult hippocampal neurogenesis in a mouse model of familial hypercholesterolemia: A role for the LDL receptor and cholesterol metabolism in adult …

DF Engel, AN Grzyb, J de Oliveira, A Pötzsch… - Molecular …, 2019 - Elsevier
Objective In familial hypercholesterolemia (FH), mutations in the low-density lipoprotein
(LDL) receptor (LDLr) gene result in increased plasma LDL cholesterol. Clinical and …

Hypercholesterolemia causes psychomotor abnormalities in mice and alterations in cortico-striatal biogenic amine neurotransmitters: relevance to Parkinson's disease

R Paul, A Choudhury, DC Boruah, R Devi… - Neurochemistry …, 2017 - Elsevier
The symptoms of Parkinson's disease (PD) include motor behavioral abnormalities, which
appear as a result of the extensive loss of the striatal biogenic amine, dopamine. Various …