Abstract p53 functions as a transcription factor involved in cell-cycle control, DNA repair,
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …

The study of human genetic disorders and mutant mouse models has provided evidence
that genome maintenance mechanisms, DNA damage signalling and metabolic regulation …

To determine the most important drivers of successful ageing at extreme old age, we
combined community-based prospective cohorts: Tokyo Oldest Old Survey on Total Health …

The attrition of telomeres, the ends of eukaryote chromosomes, is thought to play an
important role in cell deterioration with advancing age. The observed variation in telomere …

Telomere length (TL) has been associated with aging and mortality, but individual
differences are also influenced by genetic factors, with previous studies reporting heritability …

Longevity and healthy aging are among the most complex phenotypes studied to date. The
heritability of age at death in adulthood is approximately 25%. Studies of exceptionally long …

Genome instability has long been implicated as the main causal factor in aging. Somatic
cells are continuously exposed to various sources of DNA damage, from reactive oxygen …

Males and females often age at different rates resulting in longevity 'gender gaps', where
one sex outlives the other. Why the sexes have different lifespans is an age‐old question …

Healthy aging and longevity in humans are modulated by a lucky combination of genetic
and non-genetic factors. Family studies demonstrated that about 25% of the variation in …

Background Even before the onset of age-related diseases, obesity might be a contributing
factor to the cumulative burden of oxidative stress and chronic inflammation throughout the …