Targeting persistent changes in neuroimmune and epigenetic signaling in adolescent drinking to treat alcohol use disorder in adulthood

FT Crews, LG Coleman, VA Macht, RP Vetreno - Pharmacological Reviews, 2023 - ASPET
Studies universally find early age of drinking onset is linked to lifelong risks of alcohol
problems and alcohol use disorder (AUD). Assessment of the lasting effect of drinking during …

[HTML][HTML] Sex-and age-specific effects on the development of addiction and compulsive-like drinking in rats

JC Foo, I Skorodumov, R Spanagel… - Biology of sex …, 2023 - Springer
Background Biological factors are known to influence disease trajectories and treatment
effectiveness in alcohol addiction and preclinical and clinical evidence suggests that sex is …

Sex differences in the effects of adolescent intermittent ethanol exposure on exploratory and anxiety-like behavior in adult rats

KL Healey, SA Kibble, A Bell, G Kramer… - Alcohol, 2022 - Elsevier
Adolescent intermittent ethanol (AIE) exposure in rodents has been shown to alter adult
behavior in several domains, including learning and memory, social interaction, affective …

[HTML][HTML] Impact of adolescent intermittent ethanol exposure on social investigation, social preference, and neuronal activation in cFos-LacZ male and female rats

TT Towner, DT Applegate, EI Varlinskaya… - Frontiers in …, 2022 - frontiersin.org
Adolescence is a sensitive developmental period during which alcohol use is often initiated
and consumed in high quantities, often at binge or even high-intensity drinking levels. Our …

[HTML][HTML] Epigenetic regulation of microglia and neurons by proinflammatory signaling following adolescent intermittent ethanol (AIE) exposure and in human AUD

FT Crews, V Macht, RP Vetreno - Advances in Drug and …, 2024 - frontierspartnerships.org
Adolescent alcohol drinking is linked to high rates of adult alcohol problems and alcohol use
disorder (AUD). The Neurobiology of Alcohol Drinking in Adulthood (NADIA) consortium …

[HTML][HTML] Acute alcohol induces greater dose-dependent increase in the lateral cortical network functional connectivity in adult than adolescent rats

SH Lee, TA Shnitko, LM Hsu, MA Broadwater… - Addiction …, 2023 - Elsevier
Alcohol misuse and, particularly adolescent drinking, is a major public health concern. While
evidence suggests that adolescent alcohol use affects frontal brain regions that are …

Adolescent intermittent ethanol exposure enhances adult stress effects in male rats

KL Healey, S Kibble, K Dubester, A Bell… - Pharmacology …, 2023 - Elsevier
Binge patterns of alcohol use, prevalent among adolescents, are associated with a higher
probability of developing alcohol use disorders (AUD) and other psychiatric disorders, like …

Determining the neuronal ensembles underlying sex-specific social impairments following adolescent intermittent ethanol exposure

TT Towner, MA Goyden, HJ Coleman, MK Drumm… - …, 2023 - Elsevier
Binge drinking during adolescence can have behavioral and neurobiological
consequences. We have previously found that adolescent intermittent ethanol (AIE) …

The influence of sex on hippocampal neurogenesis and neurotrophic responses on the persistent effects of adolescent intermittent ethanol exposure into adulthood

KN Nwachukwu, KL Healey, HS Swartzwelder… - Neuroscience, 2022 - Elsevier
Abstract In the United States, approximately 90% of alcohol consumed by adolescents is
binge drinking. Binge-like ethanol exposure during adolescence promotes dysregulation of …

[HTML][HTML] Adolescent alcohol exposure persistently alters orbitofrontal cortical encoding of Pavlovian conditional stimulus components in female rats

JA Pochapski, A Gómez-A, SJ Stringfield, H Jaggers… - Scientific Reports, 2024 - nature.com
Exposure to alcohol during adolescence impacts cortical and limbic brain regions
undergoing maturation. In rodent models, long-term effects on behavior and …