[HTML][HTML] Role of Neuropilin-2-mediated signaling axis in cancer progression and therapy resistance

R Islam, J Mishra, S Bodas, S Bhattacharya… - Cancer and Metastasis …, 2022 - Springer
Neuropilins (NRPs) are transmembrane proteins involved in vascular and nervous system
development by regulating angiogenesis and axon guidance cues. Several published …

Cancer stem cell in prostate cancer progression, metastasis and therapy resistance

P Verma, N Shukla, S Kumari, MS Ansari… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Prostate cancer (PCa) is the most diagnosed malignancy in the men worldwide. Cancer
stem cells (CSCs) are the sub-population of cells present in the tumor which possess unique …

Deficiency of inflammation‐sensing protein neuropilin‐2 in myeloid‐derived macrophages exacerbates colitis via NF‐κB activation

T Li, J Ran, Z Miao, M Yang, D Mou… - The Journal of …, 2024 - Wiley Online Library
Abstract Neuropilin‐2 (NRP2) is a multifunctional protein engaged in the regulation of
angiogenesis, lymphangiogenesis, axon guidance, and tumor metastasis, but its function in …

[HTML][HTML] The osteoclast traces the route to bone tumors and metastases

S Russo, F Scotto di Carlo… - Frontiers in Cell and …, 2022 - frontiersin.org
Osteoclasts are highly specialized cells of the bone, with a unique apparatus responsible for
resorption in the process of bone remodeling. They are derived from differentiation and …

A novel cancer stemness‐related signature for predicting prognosis in patients with colon adenocarcinoma

W Wang, C Xu, Y Ren, S Wang, C Liao… - Stem cells …, 2021 - Wiley Online Library
Objective. To explore the cancer stemness features and develop a novel cancer stemness‐
related prognostic signature for colon adenocarcinoma (COAD). Methods. We downloaded …

Neuropilin-2 promotes lineage plasticity and progression to neuroendocrine prostate cancer

J Wang, J Li, L Yin, T Pu, J Wei, V Karthikeyan, TP Lin… - Oncogene, 2022 - nature.com
Neuroendocrine prostate cancer (NEPC), a lethal subset of prostate cancer, is characterized
by loss of AR signaling and resulting resistance to AR-targeted therapy during …

Neuropilin-2 regulates androgen-receptor transcriptional activity in advanced prostate cancer

S Dutta, NS Polavaram, R Islam, S Bhattacharya… - Oncogene, 2022 - nature.com
Aberrant transcriptional activity of androgen receptor (AR) is one of the dominant
mechanisms for developing of castration-resistant prostate cancer (CRPC). Analyzing AR …

[HTML][HTML] Immune-related gene signature associates with immune landscape and predicts prognosis accurately in patients with Wilms tumour

XM Tian, B Xiang, LM Jin, T Mi, JK Wang… - Frontiers in …, 2022 - frontiersin.org
Wilms tumour (WT) is the most common kidney malignancy in children. Chemoresistance is
the leading cause of tumour recurrence and poses a substantial therapeutic challenge …

[HTML][HTML] Neuropilin 2 in osteoblasts regulates trabecular bone mass in male mice

L Verlinden, S Doms, I Janssens, MB Meyer… - Frontiers in …, 2023 - frontiersin.org
Introduction Neuropilin 2 (NRP2) mediates the effects of class 3 semaphorins and vascular
endothelial growth factor and is implicated in axonal guidance and angiogenesis. Moreover …

[HTML][HTML] Animal models of cancer metastasis to the bone

Y Yu, K Li, Y Peng, W Wu, F Chen, Z Shao… - Frontiers in …, 2023 - frontiersin.org
Cancer metastasis is a major cause of mortality from several tumors, including those of the
breast, prostate, and the thyroid gland. Since bone tissue is one of the most common sites of …