70 years have passed since the first isolation of the naphthodianthrones hypericin and
pseudohypericin from Hypericum perforatum L. Today, they continue to be one of the most …

Abstract The 90-kiloDalton (kD) heat shock protein (Hsp90) is a ubiquitous, ATP-dependent
molecular chaperone whose primary function is to ensure the proper folding of several …

Hypericin, an extract from St John's Wort (Hypericum perforatum L.), is a promising
photosensitizer in the context of clinical photodynamic therapy due to its excellent …

Depression is a major neuropsychiatric disease that considerably impacts individuals'
psychosocial function and life quality. Neurotrophic factors are now connected to the …

Octacosanol is a long-chain aliphatic alcohol, which is the main component of policosanol
used as a normolipidemic agent. It is known that angiogenesis is involved in tumor growth …

Osteoclast-induced bone resorption and wear-particle-induced osteolysis leads to prosthetic
loosening, one of the most common causes of joint implant failure, resulting in revision …

Ethnopharmacological relevance: Hypericum perforatum L. is a traditional Chinese
medicine used to sooth the liver, relieve depression, reduce body temperature, reduce …

The perihydroxylated perylene quinone hypericin has been reported to possess potent anti-
metastatic and antiangiogenic activities, generated by targeting diverse crossroads of …

Subcellular localization of a photosensitizer is critical to its therapeutic outcome during
photodynamic therapy (PDT). We delineated the distribution of hypericin, a new generation …

The purpose of this study was to evaluate the effects of the use of the subconjunctival
injection of bevacizumab (Avastin®) on angiogenesis in the rat cornea. Corneas of 20 Wistar …