Given the worldwide epidemic of diet-related chronic diseases, evidence-based dietary
recommendations are fundamentally important for health promotion. Despite the importance …

Cruciferous vegetables hold a myriad of bioactive molecules that are renowned for
possessing unique medicinal benefits. Sulforaphane (SFN) is one of the potential …

Members of the human gut microbiome enzymatically process many bioactive molecules in
the gastrointestinal tract. Most gut bacterial modifications characterized so far are hydrolytic …

Harnessing the microbiota for beneficial outcomes is limited by our poor understanding of
the constituent bacteria, as the functions of most of their genes are unknown. Here, we …

BACKGROUND Identifying factors conferring responses to therapy in cancer is critical to
select the best treatment for patients. For immune checkpoint inhibition (ICI) therapy …

Gut microbial transformations of flavonoids, an enormous class of polyphenolic compounds
abundant in plant-based diets, are closely associated with human health. However, the …

Plant natural products include a diverse array of compounds that play important roles in
plant metabolism and physiology. After elucidation of biosynthetic pathways and regulatory …

Glucosinolates (GLS) and their derivatives are secondary plant metabolites abundant in
Brassicaceae. Due to the enzymatic reaction between GLS and myrosinase enzyme …

Glucosinolates and their metabolites from Brassicaceae plants have received widespread
attention due to their anti-inflammatory effects. Glucosinolates occurs an “enterohepatic …

Plant specialized metabolites (PSMs) are variably distributed across taxa, tissues, and
ecological contexts; this variability has inspired many theories about PSM function, which to …