Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

Metabolomics, which is the profiling of metabolites in biofluids, cells and tissues, is routinely
applied as a tool for biomarker discovery. Owing to innovative developments in informatics …

The heart consumes circulating nutrients to fuel lifelong contraction, but a comprehensive
mapping of human cardiac fuel use is lacking. We used metabolomics on blood from artery …

Mammalian organs continually exchange metabolites via circulation, but systems-level
analysis of this shuttling process is lacking. Here, we compared, in fasted pigs, metabolite …

Alpha-ketoglutarate (AKG) is an intermediate in the Krebs cycle involved in various
metabolic and cellular pathways. As an antioxidant, AKG interferes in nitrogen and ammonia …

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause
cystic fibrosis (CF), a multiorgan disease that is characterized by diverse metabolic defects …

Transcriptomics data have been integrated with genome-wide association studies (GWASs)
to help understand disease/trait molecular mechanisms. The utility of metabolomics …

Altered metabolic activity contributes to the pathogenesis of a number of diseases, including
diabetes, heart failure, cancer, fibrosis and neurodegeneration. These diseases, and …

Human cells are able to sense and adapt to variations in oxygen levels. Historically, much
research in this field has focused on hypoxia-inducible factor (HIF) signaling and reactive …

Brain function is highly dependent upon controlled energy metabolism whose loss heralds
cognitive impairments. This is particularly notable in the aged individuals and in age-related …