Being the most common musculoskeletal progressive condition, osteoarthritis is an
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …

Research into the molecular genetics of osteoarthritis (OA) has been substantially bolstered
in the past few years by the implementation of powerful genome-wide scans that have …

Osteoarthritis (OA) is the most common degenerative joint disease that causes painful
swelling and permanent damage to the joints in the body. The molecular mechanisms of OA …

Articular chondrocytes are quiescent, fully differentiated cells responsible for the
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …

Objective In this review, we have highlighted advances in genetics, genomics and
epigenetics in the field of osteoarthritis (OA) over the past year. Methods A literature search …

The kidney is a mitochondria-rich organ, and kidney diseases are recognized as
mitochondria-related pathologies. Intact mitochondrial DNA (mtDNA) maintains normal …

Articular cartilage function depends on the temporal and zonal distribution of coordinated
metabolic regulation in chondrocytes. Emerging evidence shows the importance of cellular …

Challenging skeletal repairs are frequently seen in patients experiencing systemic
inflammation. To tackle the complexity and heterogeneity of the skeletal repair process, we …

Osteoarthritis (OA) is an age-associated disease characterized by chronic joint pain
resulting from degradation of articular cartilage, inflammation of the synovial lining, and …

Glucose metabolism is fundamental for the functions of all tissues, including cartilage.
Despite the emerging evidence related to glucose metabolism in the regulation of prenatal …