Does the shape of the electric pulse matter in electroporation?

V Novickij, N Rembiałkowska, W Szlasa… - Frontiers in …, 2022 - frontiersin.org
Electric pulses are widely used in biology, medicine, industry, and food processing.
Numerous studies indicate that electroporation (EP) is a pulse-dependent process, and the …

From the basic science of biological effects of ultrashort electrical pulses to medical therapies

KH Schoenbach - Bioelectromagnetics, 2018 - Wiley Online Library
This article is based on my presentation at the D'Arsonval Ceremony at the Joint Annual
Meeting of the Bioelectromagnetics Society and the European BioElectromagnetics …

Excitation and electroporation by MHz bursts of nanosecond stimuli

AG Pakhomov, S Xiao, V Novickij, M Casciola… - Biochemical and …, 2019 - Elsevier
Intense nanosecond pulsed electric field (nsPEF) is a novel modality for cell activation and
nanoelectroporation. Applications of nsPEF in research and therapy are hindered by a high …

Calcium-independent disruption of microtubule dynamics by nanosecond pulsed electric fields in U87 human glioblastoma cells

L Carr, SM Bardet, RC Burke, D Arnaud-Cormos… - Scientific reports, 2017 - nature.com
High powered, nanosecond duration, pulsed electric fields (nsPEF) cause cell death by a
mechanism that is not fully understood and have been proposed as a targeted cancer …

High frequency electroporation efficiency is under control of membrane capacitive charging and voltage potential relaxation

V Novickij, P Ruzgys, A Grainys, S Šatkauskas - Bioelectrochemistry, 2018 - Elsevier
The study presents the proof of concept for a possibility to achieve a better electroporation in
the MHz pulse repetition frequency (PRF) region compared to the conventional low …

Asymmetrical bipolar nanosecond electric pulse widths modify bipolar cancellation

CM Valdez, RA Barnes Jr, CC Roth, EK Moen… - Scientific reports, 2017 - nature.com
A bipolar (BP) nanosecond electric pulse (nsEP) exposure generates reduced calcium influx
compared to a unipolar (UP) nsEP. This attenuated physiological response from a BP nsEP …

Transport of charged small molecules after electropermeabilization—drift and diffusion

EB Sözer, CF Pocetti, PT Vernier - BMC biophysics, 2018 - Springer
Background Applications of electric-field-induced permeabilization of cells range from
cancer therapy to wastewater treatment. A unified understanding of the underlying …

Single-cell electroporation with high-frequency nanosecond pulse bursts: Simulation considering the irreversible electroporation effect and experimental validation

Y Mi, J Xu, Q Liu, X Wu, Q Zhang, J Tang - Bioelectrochemistry, 2021 - Elsevier
To study the electroporation characteristics of cells under high-frequency nanosecond pulse
bursts (HFnsPBs), the original electroporation mathematical model was improved. By setting …

Characterization of Cell Membrane Permeability In Vitro Part II: Computational Model of Electroporation-Mediated Membrane Transport

DC Sweeney, TA Douglas… - Technology in cancer …, 2018 - journals.sagepub.com
Electroporation is the process by which applied electric fields generate nanoscale defects in
biological membranes to more efficiently deliver drugs and other small molecules into the …

Dye transport through bilayers agrees with lipid electropore molecular dynamics

EB Sözer, S Haldar, PS Blank, F Castellani… - Biophysical journal, 2020 - cell.com
Although transport of molecules into cells via electroporation is a common biomedical
procedure, its protocols are often based on trial and error. Despite a long history of …