Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

Tau is a protein that is highly enriched in neurons and was originally defined by its ability to
bind and stabilize microtubules. However, it is now becoming evident that the functions of …

Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized
pathologically by extracellular deposition of β-amyloid (Aβ) into senile plaques and …

Tau is a microtubule-associated protein and a key regulator of microtubule stabilization as
well as the main component of neurofibrillary tangles—a principle neuropathological …

c-Jun N-terminal kinase 3 (JNK3) is suggested to play a key role in neurodegenerative
disorders, especially in Alzheimer's disease (AD). However, it remains unclear whether JNK …

Intracellular neurofibrillary tangles (NFT) composed by tau and extracellular amyloid beta
(Aβ) plaques accumulate in Alzheimer's disease (AD) and contribute to neuronal …

Abstract Alzheimer's disease (AD), the most common progressive neurodegenerative
disorder, is characterized by severe cognitive decline and personality changes as a result of …

Microtubule-associated protein tau (MAPT/tau) accumulates in a family of
neurodegenerative diseases, including Alzheimer's disease (AD). In disease, tau is …

Background Tauopathies are a class of neurodegenerative illnesses associated with the
aberrant accumulation of the tau protein in the brain. The best known out of these diseases …

Tau protein plays a pivotal role in the central nervous system (CNS), participating in
microtubule stability, axonal transport, and synaptic communication. Research interest has …