Statin-associated muscle symptoms (SAMS) are one of the principal reasons for statin non-
adherence and/or discontinuation, contributing to adverse cardiovascular outcomes. This …

Probiotics are live microorganisms that promote health benefits upon consumption, while
prebiotics are nondigestible food ingredients that selectively stimulate the growth of …

The use of probiotics as food components combats not only cardiovascular diseases but
also many gastrointestinal tract disorders. Their health benefits along with their increased …

The ease of breeding, low cost of maintenance, and relatively short period for developing
atherosclerosis make rodents ideal for atherosclerosis research. However, none of the …

We investigated the role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in the
resistance of dyslipidemic hamsters to statin-induced LDL-cholesterol (LDL-C) reduction …

Abstract Over 30 years ago Professor David Barker first proposed the theory that events in
early life could explain an individual's risk of non‐communicable disease in later life: the …

Rationale: The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, are
important drugs used in the treatment and prevention of cardiovascular disease. Although …

Background About 4.6 million persons in Germany are now taking statins, ie, drugs that
inhibit the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. Statins …

Type 2 diabetes is a leading cause of morbidity and mortality among noncommunicable
diseases, and additional animal models that more closely replicate the pathogenesis of …

The increased uptake and storage of lipids in the liver are important features of steatotic liver
diseases. The fatty acid translocase/scavenger receptor cluster of differentiation (CD) 36 …