Age and sex are critical factors in ischemic stroke pathology
M Roy-O'Reilly, LD McCullough - Endocrinology, 2018 - academic.oup.com
Ischemic stroke is a devastating brain injury resulting in high mortality and substantial loss of
function. Understanding the pathophysiology of ischemic stroke risk, mortality, and functional …
function. Understanding the pathophysiology of ischemic stroke risk, mortality, and functional …
Preeclampsia: from cellular wellness to inappropriate cell death, and the roles of nutrition
Preeclampsia is one of the most common obstetrical complications worldwide. The
pathomechanism of this disease begins with abnormal placentation in early pregnancy …
pathomechanism of this disease begins with abnormal placentation in early pregnancy …
[HTML][HTML] Placental epigenetic clocks: estimating gestational age using placental DNA methylation levels
The human pan-tissue epigenetic clock is widely used for estimating age across the entire
lifespan, but it does not lend itself well to estimating gestational age (GA) based on placental …
lifespan, but it does not lend itself well to estimating gestational age (GA) based on placental …
Sexual epigenetic dimorphism in the human placenta: implications for susceptibility during the prenatal period
E Martin, L Smeester, PA Bommarito, MR Grace… - …, 2017 - Taylor & Francis
Aim: Sex-based differences in response to adverse prenatal environments and infant
outcomes have been observed, yet the underlying mechanisms for this are unclear. The …
outcomes have been observed, yet the underlying mechanisms for this are unclear. The …
Current approaches and developments in transcript profiling of the human placenta
BACKGROUND The placenta is the active interface between mother and foetus, bearing the
molecular marks of rapid development and exposures in utero. The placenta is routinely …
molecular marks of rapid development and exposures in utero. The placenta is routinely …
Trophoblast differentiation: mechanisms and implications for pregnancy complications
Placental development is a tightly controlled event, in which cell expansion from the
trophectoderm occurs in a spatiotemporal manner. Proper trophoblast differentiation is …
trophectoderm occurs in a spatiotemporal manner. Proper trophoblast differentiation is …
Placental programming, perinatal inflammation, and neurodevelopment impairment among those born extremely preterm
Individuals born extremely preterm are at significant risk for impaired neurodevelopment.
After discharge from the neonatal intensive care, associations between the child's well-being …
After discharge from the neonatal intensive care, associations between the child's well-being …
TGFb1 suppresses the activation of distinct dNK subpopulations in preeclampsia
J Zhang, CE Dunk, O Shynlova, I Caniggia, SJ Lye - EBioMedicine, 2019 - thelancet.com
Background Decidual natural killer (dNK) cells are the predominant lymphocytes
accumulated at the maternal-fetal interface. Regulatory mechanism of dNK cells in …
accumulated at the maternal-fetal interface. Regulatory mechanism of dNK cells in …
Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome
The placenta is the interface between maternal and fetal circulations, integrating maternal
and fetal signals to selectively regulate nutrient, gas, and waste exchange, as well as …
and fetal signals to selectively regulate nutrient, gas, and waste exchange, as well as …
Alterations in the placental methylome with maternal obesity and evidence for metabolic regulation
The inflammatory and metabolic derangements of obesity in pregnant women generate an
adverse intrauterine environment, increase pregnancy complications and adverse fetal …
adverse intrauterine environment, increase pregnancy complications and adverse fetal …