Can we predict T cell specificity with digital biology and machine learning?
Recent advances in machine learning and experimental biology have offered breakthrough
solutions to problems such as protein structure prediction that were long thought to be …
solutions to problems such as protein structure prediction that were long thought to be …
Epigenetic regulation of T cell exhaustion
Chronic antigen stimulation during viral infections and cancer can lead to T cell exhaustion,
which is characterized by reduced effector function and proliferation, and the expression of …
which is characterized by reduced effector function and proliferation, and the expression of …
Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence
T cell exhaustion limits antitumor immunity, but the molecular determinants of this process
remain poorly understood. Using a chronic stimulation assay, we performed genome-wide …
remain poorly understood. Using a chronic stimulation assay, we performed genome-wide …
[HTML][HTML] Ketolysis drives CD8+ T cell effector function through effects on histone acetylation
KM Luda, J Longo, SM Kitchen-Goosen, LR Duimstra… - Immunity, 2023 - cell.com
Environmental nutrient availability influences T cell metabolism, impacting T cell function
and shaping immune outcomes. Here, we identified ketone bodies (KBs)—including β …
and shaping immune outcomes. Here, we identified ketone bodies (KBs)—including β …
Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure
Summary Rewiring exhausted CD8+ T (Tex) cells toward functional states remains a
therapeutic challenge. Tex cells are epigenetically programmed by the transcription factor …
therapeutic challenge. Tex cells are epigenetically programmed by the transcription factor …
Stem-like exhausted and memory CD8+ T cells in cancer
T Gebhardt, SL Park, IA Parish - Nature Reviews Cancer, 2023 - nature.com
T cells can acquire a broad spectrum of differentiation states following activation. At the
extreme ends of this continuum are short-lived cells equipped with effector machinery and …
extreme ends of this continuum are short-lived cells equipped with effector machinery and …
Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity
Summary Relatlimab (rela; anti-LAG-3) plus nivolumab (nivo; anti-PD-1) is safe and effective
for treatment of advanced melanoma. We designed a trial (NCT03743766) where advanced …
for treatment of advanced melanoma. We designed a trial (NCT03743766) where advanced …
The advent of immune stimulating CAFs in cancer
M Tsoumakidou - Nature Reviews Cancer, 2023 - nature.com
The theory that cancer-associated fibroblasts (CAFs) are immunosuppressive cells has
prevailed throughout the past decade. However, recent high-throughput, high-resolution …
prevailed throughout the past decade. However, recent high-throughput, high-resolution …
LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity
Summary Exhausted CD8 T (T ex) cells in chronic viral infection and cancer have sustained
co-expression of inhibitory receptors (IRs). T ex cells can be reinvigorated by blocking IRs …
co-expression of inhibitory receptors (IRs). T ex cells can be reinvigorated by blocking IRs …