Spine dynamics in the brain, mental disorders and artificial neural networks
In the brain, most synapses are formed on minute protrusions known as dendritic spines.
Unlike their artificial intelligence counterparts, spines are not merely tuneable memory …
Unlike their artificial intelligence counterparts, spines are not merely tuneable memory …
Autism spectrum disorder: neuropathology and animal models
M Varghese, N Keshav, S Jacot-Descombes… - Acta …, 2017 - Springer
Autism spectrum disorder (ASD) has a major impact on the development and social
integration of affected individuals and is the most heritable of psychiatric disorders. An …
integration of affected individuals and is the most heritable of psychiatric disorders. An …
Dendritic spine plasticity: function and mechanisms
K Runge, C Cardoso, A De Chevigny - Frontiers in synaptic …, 2020 - frontiersin.org
Dendritic spines are small protrusions studding neuronal dendrites, first described in 1888
by Ramón y Cajal using his famous Golgi stainings. Around 50 years later the advance of …
by Ramón y Cajal using his famous Golgi stainings. Around 50 years later the advance of …
MMPs in learning and memory and neuropsychiatric disorders
Matrix metalloproteinases (MMPs) are a group of over twenty proteases, operating chiefly
extracellularly to cleave components of the extracellular matrix, cell adhesion molecules as …
extracellularly to cleave components of the extracellular matrix, cell adhesion molecules as …
Representational drift as a window into neural and behavioural plasticity
Large-scale recordings of neural activity over days and weeks have revealed that neural
representations of familiar tasks, precepts and actions continually evolve without obvious …
representations of familiar tasks, precepts and actions continually evolve without obvious …
Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory
Modeling studies suggest that clustered structural plasticity of dendritic spines is an efficient
mechanism of information storage in cortical circuits. However, why new clustered spines …
mechanism of information storage in cortical circuits. However, why new clustered spines …
[HTML][HTML] Aberrant RNA translation in fragile X syndrome: From FMRP mechanisms to emerging therapeutic strategies
Research in the past decades has unfolded the multifaceted role of Fragile X mental
retardation protein (FMRP) and how its absence contributes to the pathophysiology of …
retardation protein (FMRP) and how its absence contributes to the pathophysiology of …
Intrinsic volatility of synaptic connections—a challenge to the synaptic trace theory of memory
Highlights•Learning induces synaptic re-organization of cortical circuits.•Substantial synaptic
re-organization also occurs spontaneously.•It is unclear what elements provide stability …
re-organization also occurs spontaneously.•It is unclear what elements provide stability …
Demystifying the extracellular matrix and its proteolytic remodeling in the brain: structural and functional insights
The extracellular matrix (ECM) plays diverse roles in several physiological and pathological
conditions. In the brain, the ECM is unique both in its composition and in functions …
conditions. In the brain, the ECM is unique both in its composition and in functions …
Synaptic tenacity or lack thereof: spontaneous remodeling of synapses
Synaptic plasticity–the directed modulation of synaptic connections by specific activity
histories or physiological signals–is believed to be a major mechanism for the modification …
histories or physiological signals–is believed to be a major mechanism for the modification …