Platelets play a key role in maintaining hemostasis. However, dysregulated platelet
activation can lead to pathological thrombosis or bleeding. Once a platelet gets activated, it …

Mechanically assisted circulation (MAC) sustains the blood circulation in the body of a
patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) or on ventricular …

Arterial thrombosis is a leading cause of death and disability worldwide with no effective
bioassay for clinical prediction. As a symbolic feature of arterial thrombosis, severe stenosis …

Background Procoagulant platelets are a subpopulation of highly activated platelets that
promote coagulation through surface-exposed, negatively charged phospholipids …

Objective: Mechanical circulatory support has emerged as lifesaving therapy for patients
with advanced heart failure. However, mechanical circulatory support remains limited by a …

Upon activation, maternal platelets provide a source of proinflammatory mediators in the
intervillous space of the placenta. Therefore, platelet-derived factors may interfere with …

Objective: Roxadustat is a new medication for the treatment of renal anemia. EPO
(erythropoietin)—the current treatment standard—has been reported to enhance platelet …

Thromboembolic events are frequently reported in patients infected with the SARS-CoV-2
virus. The exact mechanisms of COVID-19-associated hypercoagulopathy, however, remain …

Procoagulant platelets are a subtype of activated platelets that sustains thrombin generation
in order to consolidate the clot and stop bleeding. This aspect of platelet activation is gaining …

Despite growing use of mechanical circulatory support, limitations remain related to
hemocompatibility. Here, we performed a head-to-head comparison of the …